Background: Previous studies reported a preserved ability to cycle in freezers, creating opportunities for restoring mobility and independence. However, use of a bicycle is not always feasible. Here, we investigated the effectiveness of a "walk-bicycle" in reducing freezing of gait (FOG).
Methods: Eighteen Parkinson patients with FOG performed the following tasks, each four times, with and without the walk-bicycle: (1) normal walking; (2) walking with small steps, at normal speed; (3) walking with small steps, as rapidly as possible.
Results: Seven patients showed FOG during walking without the walk-bicycle. In those patients, the walk-bicycle afforded a 12% reduction of time frozen (p = 0.026). In 11 patients no FOG was observed during walking without the walk-bicycle. Two of them showed FOG when using the walk-bicycle.
Conclusions: The walk-bicycle may help to reduce FOG in some patients, but not in all. Future studies need to evaluate its usefulness in a home environment.
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http://dx.doi.org/10.1016/j.parkreldis.2015.04.025 | DOI Listing |
Nat Med
January 2025
Department of Medicine-Medical Oncology, University of Colorado Cancer Center, Denver, CO, USA.
Effective targeting of somatic cancer mutations to enhance the efficacy of cancer immunotherapy requires an individualized approach. Autogene cevumeran is a uridine messenger RNA lipoplex-based individualized neoantigen-specific immunotherapy designed from tumor-specific somatic mutation data obtained from tumor tissue of each individual patient to stimulate T cell responses against up to 20 neoantigens. This ongoing phase 1 study evaluated autogene cevumeran as monotherapy (n = 30) and in combination with atezolizumab (n = 183) in pretreated patients with advanced solid tumors.
View Article and Find Full Text PDFRehabil Psychol
January 2025
Department of Applied Clinical Research, UT Southwestern Medical Center.
Unlabelled: One common gait issue associated with advanced Parkinson's disease (PD) is freezing of gait (FoG). FoG impacts approximately half of people with PD and negatively impacts quality of life. Studies have suggested that anxiety may contribute to FoG.
View Article and Find Full Text PDFFront Aging Neurosci
December 2024
Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Background: The neural mechanisms underlying freezing of gait (FOG) in Parkinson's disease (PD) have not been completely comprehended. Sensory-motor integration dysfunction was proposed as one of the contributing factors. Here, we investigated short-latency afferent inhibition (SAI) and long-latency afferent inhibition (LAI), and analyzed their association with gait performance in FOG PD patients, to further validate the role of sensorimotor integration in the occurrence of FOG in PD.
View Article and Find Full Text PDFSleep Health
December 2024
Boston Children's Hospital, Boston, Massachusetts, United States; Harvard Medical School, Boston, Massachusetts, United States; Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States; Dana-Farber Cancer Institute, Boston, Massachusetts, United States.
Objectives: People with idiopathic hypersomnia report significant impairment in their lives due to idiopathic hypersomnia symptoms, and this likely includes an impact on social relationship health. This study investigated the effects of idiopathic hypersomnia on social relationships (friends, romantic, and sexual) during the key developmental period of young adulthood.
Methods: Young adults (N = 106; 18-39years) with idiopathic hypersomnia were recruited through national hypersomnia patient organizations.
Brain Behav
January 2025
Department of Biomedical Engineering, Meybod University, Meybod, Iran.
Purpose: A debilitating and poorly understood symptom of Parkinson's disease (PD) is freezing of gait (FoG), which increases the risk of falling. Clinical evaluations of FoG, relying on patients' subjective reports and manual examinations by specialists, are unreliable, and most detection methods are influenced by subject-specific factors.
Method: To address this, we developed a novel algorithm for detecting FoG events based on movement signals.
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