We investigated the impact of oxygenation status (measured by EPR oximetry) on the uptake of (18)F-FDG (measured by PET) in two different tumor models during a carbogen breathing challenge. We observed a significant drop in (18)F-FDG uptake under carbogen breathing that suggests a rapid metabolic adaptation to the oxygen environment.
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| http://dx.doi.org/10.1016/j.radonc.2015.04.023 | DOI Listing |
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Impact of acute sleep restriction on cerebrovascular reactivity and neurovascular coupling in young men and women.
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Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, United States.
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Department of hyperbaric and diving medicine. Hôpital d'instruction des armées Sainte-Anne. Toulon armées, France.
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Int J Radiat Oncol Biol Phys
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Radiation Oncology Laboratory, Department of Radiation Oncology, Lausanne, University Hospital and University of Lausanne, Lausanne, Switzerland. Electronic address:
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The monitoring of acidosis and hypoxia is crucial because both factors promote cancer progression and impact the efficacy of anti-cancer treatments. A phosphonated tetrathiatriarylmethyl (pTAM) has been previously described to monitor both parameters simultaneously, but the sensitivity to tackle subtle changes in oxygenation was limited. Here, we describe an innovative approach combining the pTAM radical and lithium phthalocyanine (LiPc) crystals to provide sensitive simultaneous measurements of extracellular pH (pH) and pO.
View Article and Find Full Text PDFReproducibility and diurnal variation in middle cerebral artery blood velocity in healthy humans.
Exp Physiol
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Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA.
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