AI Article Synopsis
- The study focused on understanding the basal metabolic rate (BMR) of children with chronic kidney disease (CKD) to see how it relates to kidney function, independent of factors like weight and height.
- The results showed that the BMR of children with CKD was not significantly different from healthy peers, suggesting that average energy requirements could be used for dietary guidelines.
- However, it was noted that children with poorer kidney function had lower metabolic rates, indicating that their energy needs may be more complex.
Article Abstract
Background: Meeting energy requirements of children with chronic kidney disease (CKD) is paramount to optimising growth and clinical outcome, but little information on this subject has been published. In this study, we examined basal metabolic rate (BMR; a component of energy expenditure) with the aim to determine whether it is related to kidney function independently of weight, height and lean body mass (LBM).
Methods: Twenty children with CKD and 20 healthy age- and gender-matched control children were studied on one occasion. BMR was measured by indirect open circuit calorimetry and predicted by the Schofield equation. Estimated glomerular filtration rate (eGFR) was related to BMR and adjusted for weight, height, age and LBM measured by skinfold thickness.
Results: The adjusted BMR of children with CKD did not differ significantly from that of healthy subjects (1296 ± 318 vs.1325 ± 178 kcal/day; p = 0.720). Percentage of predicted BMR also did not differ between the two groups (102 ± 12% vs. 99 ± 14%; p = 0.570). Within the CKD group, eGFR (mean 33.7 ± 20.5 mL/min/m(2)) was significantly related to BMR (β 0.3, r = 0.517, p = 0.019) independently of nutritional status and LBM.
Conclusions: It seems reasonable to use estimated average requirement as the basis of energy prescriptions for children with CKD (mean CKD stage 3 disease). However, those who were sicker had significantly lower metabolic rates.
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| http://dx.doi.org/10.1007/s00467-015-3095-5 | DOI Listing |
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