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The role of ORMDL proteins, guardians of cellular sphingolipids, in asthma.
Allergy
July 2016
Laboratory of Signal Transduction, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
A family of widely expressed ORM-like (ORMDL) proteins has been recently linked to asthma in genomewide association studies in humans and extensively explored in in vivo studies in mice. ORMDL proteins are key regulators of serine palmitoyltransferase, an enzyme catalyzing the initial step of sphingolipid biosynthesis. Sphingolipids play prominent roles in cell signaling and response to stress, and they affect the mechanistic properties of cellular membranes.
View Article and Find Full Text PDFORMDL deregulation increases stress responses and modulates repair pathways in Drosophila airways.
J Allergy Clin Immunol
October 2015
Department of Molecular Physiology, Institute of Zoology, Christian-Albrechts University Kiel, Kiel, Germany; Airway Research Center North, German Center for Lung Research (DZL), Germany. Electronic address:
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