Conventional studies of biomolecular behaviors rely largely on the construction of kinetic schemes. Since the selection of these networks is not unique, a concern is raised whether and under which conditions hierarchical schemes can reveal the same experimentally measured fluctuating behaviors and unique fluctuation related physical properties. To clarify these questions, we introduce stochasticity into the traditional lumping analysis, generalize it from rate equations to chemical master equations and stochastic differential equations, and extract the fluctuation relations between kinetically and thermodynamically equivalent networks under intrinsic and extrinsic noises. The results provide a theoretical basis for the legitimate use of low-dimensional models in the studies of macromolecular fluctuations and, more generally, for exploring stochastic features in different levels of contracted networks in chemical and biological kinetic systems.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1063/1.4919952 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Generating "Différance" or an Ontology That Is Same Old Same Old Comment on "The Generative Mechanisms of Financial Strain and Financial Well-Being: A Critical Realist Analysis of Ideology and Difference".
Int J Health Policy Manag
December 2024
School of Health Administration, Faculty of Health, Dalhousie University, Halifax, NS, Canada.
Glenn and colleagues carefully conducted a realist review of initiatives introduced in high-income countries intended to improve financial well-being (FWB) or reduce financial strain (FS) during the early days of the pandemic. They found that these initiatives were underpinned by either neoliberal or social equity ideologies, within which, social location acted on different groups. In this commentary, we suggest caution in applying labels such as neoliberalism and social equity when lumping social welfare policies; labour policies; housing and financial services policies; and service provision for health, seniors, childcare, and education across welfare state regimes.
View Article and Find Full Text PDF"Where are you really from?": a qualitative study of Asian American medical provider experiences.
Adv Health Sci Educ Theory Pract
November 2024
Department of Internal Medicine, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, UT, USA.
The COVID-19 pandemic highlighted how racially minoritized patients and clinicians have suffered racial discrimination. It also made visible the ways in which Asians across the globe experience racial hate and illuminated that the experiences of Asians in medicine are not often spotlighted. In the United States specifically, Asian Americans are not viewed as minoritized in medicine, yet their professional experiences are rarely highlighted.
View Article and Find Full Text PDFExploring methodological approaches used in network meta-analysis of psychological interventions: A scoping review.
Res Synth Methods
November 2024
The Research Unit of Evidence Synthesis (TRUES), Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand.
Psychological interventions are complex in nature and have been shown to benefit various clinical outcomes. Gaining insight into current practices would help identify specific aspects that need improvement to enhance the quality of network meta-analysis (NMA) in this field. This scoping review aimed to explore methodological approaches in the NMA of psychological interventions.
View Article and Find Full Text PDFTwo-temperature thermochemical nonequilibrium model based on the coarse-grained treatment of molecular vibrational states.
Phys Rev E
September 2024
State Key Laboratory of High Temperature Gas Dynamics, Institute of Mechanics, Chinese Academy of Sciences, Beijing 100190, China.
Although the high-fidelity state-to-state (StS) model accurately describes high-temperature thermochemical nonequilibrium flows, its practical application is hindered by the prohibitively high computational cost. In this paper, we develop a reduced-order model that leverages the widely used two-temperature (2T) framework and a coarse-grained treatment of molecular vibrational states to achieve accuracy comparable to the StS model while ensuring computational efficiency. We observe that the multigroup coarse-grained model (CGM), lumping vibrational energy levels into several groups, yields results close to the StS model for the high-temperature postshock oxygen flows, even using only two groups.
View Article and Find Full Text PDFImproving mass lumping and stiffness parameters of bar and hinge model for accurate modal dynamics of origami structures.
Philos Trans A Math Phys Eng Sci
October 2024
Department of Civil Engineering, Indian Institute of Technology Madras, Chennai 600036, India.
The bar and hinge framework uses truss elements and rotational springs to efficiently model the structural behaviour of origami. The framework is especially useful to investigate origami metamaterials as they have repeating geometry, which makes conventional finite element simulations very expensive due to a large number of degrees of freedom. This work proposes improvements to the parameters of bar and hinge model within the context of structural dynamics, specifically modal analysis under small deformations, which has not been carried out previously in the literature.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!