Seventy-eight opiate abusers were followed up after successful in-patient detoxification in order to examine renewed opiate use. The greatest number of initial lapses occurred within a week of subjects leaving in-patient treatment. Eleven categories of lapse precipitant were identified: cognitive, mood, external, withdrawal, interpersonal, leaving a protected environment, drug availability, drug-related cues, craving, priming, and social pressure. Cognitions, negative moods and external events emerged as the most commonly mentioned factors; these often occurred together, either in clusters or in a sequence. Implications of these results for models of relapse and for treatment approaches are discussed.
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http://dx.doi.org/10.1192/bjp.154.3.354 | DOI Listing |
Protein Sci
February 2025
Department of Physics, University of Washington, Seattle, Washington, USA.
Proteins' flexibility is a feature in communicating changes in cell signaling instigated by binding with secondary messengers, such as calcium ions, associated with the coordination of muscle contraction, neurotransmitter release, and gene expression. When binding with the disordered parts of a protein, calcium ions must balance their charge states with the shape of calcium-binding proteins and their versatile pool of partners depending on the circumstances they transmit. Accurately determining the ionic charges of those ions is essential for understanding their role in such processes.
View Article and Find Full Text PDFAntibiotics (Basel)
January 2025
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, Italy.
Surgical site infections are a serious public health concern, representing a significant burden on healthcare systems and society. Their occurrence is influenced by several factors, including patient demographics, healthcare facilities and the specific circumstances surrounding surgery. The use of prophylactic antibiotics in this context carries both potential benefits and risks.
View Article and Find Full Text PDFBiomedicines
January 2025
School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT) Deemed to be University, Bhubaneswar 751024, Odisha, India.
: Cancer is caused by disruptions in the homeostatic state of normal cells, which results in dysregulation of the cell cycle, and uncontrolled growth and proliferation in affected cells to form tumors. Successful development of tumorous cells proceeds through the activation of pathways promoting cell development and functionality, as well as the suppression of immune signaling pathways; thereby providing these cells with proliferative advantages, which subsequently metastasize into surrounding tissues. These effects are primarily caused by the upregulation of oncogenes, of which SPP1 (secreted phosphoprotein 1), a non-collagenous bone matrix protein, is one of the most well-known.
View Article and Find Full Text PDFGerontologist
January 2025
MRC Unit for Lifelong Health and Ageing, University College London, UK.
Background And Objectives: This paper aims to add to the literature on successful ageing in minoritized ethnic groups. Concurring with the critiques of 'successful ageing' for focusing on values and abilities more attainable by white middle-class older people, it explores alternative discourses according to which older people from minoritized groups consider themselves to be 'ageing well'.
Research Design And Methods: The paper draws on original empirical material derived from a longitudinal research project focused on five minority ethnic groups living in a city (and surrounding areas) of the UK known for its diverse population.
J Forensic Sci
January 2025
Department of Entomology, Texas A&M University, College Station, Texas, USA.
The house fly, Musca domestica, L. (Diptera: Muscidae), is a filth fly that is often associated with criminal and civil investigations surrounding abuse, neglect, and death of humans and other vertebrates. However, development data, which are crucial for determining the age of immatures collected under forensically relevant circumstances, are limited.
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