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Biomaterials for pelvic floor reconstructive surgery: how can we do better? | LitMetric

AI Article Synopsis

  • * The trend over the last 20 years has been to use synthetic and biological materials to reinforce surgical repairs, but no current biomaterial is considered ideal for long-term success.
  • * Successful biomaterials induce limited inflammation and promote constructive remodeling, whereas those causing chronic inflammation lead to poorer outcomes; this review explores these effects based on animal and human studies.

Article Abstract

Stress urinary incontinence (SUI) and pelvic organ prolapse (POP) are major health issues that detrimentally impact the quality of life of millions of women worldwide. Surgical repair is an effective and durable treatment for both conditions. Over the past two decades there has been a trend to enforce or reinforce repairs with synthetic and biological materials. The determinants of surgical outcome are many, encompassing the physical and mechanical properties of the material used, and individual immune responses, as well surgical and constitutional factors. Of the current biomaterials in use none represents an ideal. Biomaterials that induce limited inflammatory response followed by constructive remodelling appear to have more long term success than biomaterials that induce chronic inflammation, fibrosis and encapsulation. In this review we draw upon published animal and human studies to characterize the changes biomaterials undergo after implantation and the typical host responses, placing these in the context of clinical outcomes.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419215PMC
http://dx.doi.org/10.1155/2015/968087DOI Listing

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