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A comprehensive collection of systems biology data characterizing the host response to viral infection. | LitMetric

AI Article Synopsis

  • The Systems Biology for Infectious Diseases Research program was created by the U.S. National Institute of Allergy and Infectious Diseases to study how hosts and pathogens interact on a systems level, primarily focusing on viral infections.
  • The program produced 47 datasets from various studies, examining responses to severe viruses such as pandemic H1N1, avian H5N1, and SARS-CoV, with validation through quality control and meta-analysis.
  • Key data and results are accessible publicly through repositories like GEO and PeptideAtlas, and tools for further research are available at the Influenza Research Database and Virus Pathogen Resource for scientists to explore viral infection responses.

Article Abstract

The Systems Biology for Infectious Diseases Research program was established by the U.S. National Institute of Allergy and Infectious Diseases to investigate host-pathogen interactions at a systems level. This program generated 47 transcriptomic and proteomic datasets from 30 studies that investigate in vivo and in vitro host responses to viral infections. Human pathogens in the Orthomyxoviridae and Coronaviridae families, especially pandemic H1N1 and avian H5N1 influenza A viruses and severe acute respiratory syndrome coronavirus (SARS-CoV), were investigated. Study validation was demonstrated via experimental quality control measures and meta-analysis of independent experiments performed under similar conditions. Primary assay results are archived at the GEO and PeptideAtlas public repositories, while processed statistical results together with standardized metadata are publically available at the Influenza Research Database (www.fludb.org) and the Virus Pathogen Resource (www.viprbrc.org). By comparing data from mutant versus wild-type virus and host strains, RNA versus protein differential expression, and infection with genetically similar strains, these data can be used to further investigate genetic and physiological determinants of host responses to viral infection.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410982PMC
http://dx.doi.org/10.1038/sdata.2014.33DOI Listing

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