Objective: In a driving simulation, we investigated the efficacy of galvanic cutaneous stimulation (GCS) provided during curves or intermittently during the whole circuit to mitigate simulator syndrome (SS).
Background: The literature on how GCS decreases SS, although scarce, has demonstrated the effectiveness of this technique. Stimulation with this and similar techniques has usually been provided in curves or continuously during the whole circuit but never intermittently. This stimulation method could generate a continued activation of processes related to GCS mitigating SS.
Method: Fifteen drivers (8 men; mean age = 25.5 years) participated in this experiment. We compared the total scores of the Simulator Sickness Questionnaire (SSQ) across three stimulation conditions: (a) curve GCS condition, whereby GCS was provided in curves; (b) intermittent GCS condition, whereby GCS was provided intermittently during the whole circuit; and (c) no-stimulation condition, whereby no stimulation was provided (baseline condition).
Results: The experimental outcomes revealed that GCS decreased SS in both the curve and intermittent stimulation conditions.
Conclusion: We provide evidence that GCS is an effective countermeasure to decrease SS. It could be applied indifferently in curves or intermittently during the whole circuit.
Application: For future interventions, we recommend the use of GCS to mitigate SS with similar intermittent stimulation programs. These programs have a crucial advantage as they are easily integrated into the simulator setup without the necessity of generating a complicated experimental design to stimulate during the curves.
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http://dx.doi.org/10.1177/0018720814554948 | DOI Listing |
Redox Rep
December 2025
Department of Hematology, Shenzhen Qianhai Shekou Pilot Free Trade Zone Hospital, Shenzhen, People's Republic of China.
Background: Regenerative medicine researches have shown that mesenchymal stem cells (MSCs) may be an effective treatment method for premature ovarian insufficiency (POI). However, the efficacy of MSCs is still limited.
Purpose: This study aims to explain whether salidroside and MSCs combination is a therapeutic strategy to POI and to explore salidroside-enhanced MSCs inhibiting ferroptosis via Keap1/Nrf2/GPX4 signaling.
Cell Commun Signal
January 2025
Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, 250022, China.
Degeneration of cochlear spiral ganglion neurons (SGNs) leads to irreversible sensorineural hearing loss (SNHL), as SGNs lack regenerative capacity. Although cochlear glial cells (GCs) have some neuronal differentiation potential, their specific identities remain unclear. This study identifies a distinct subpopulation, Frizzled10 positive (FZD10+) cells, as an important type of GC responsible for neuronal differentiation in mouse cochlea.
View Article and Find Full Text PDFIntern Emerg Med
January 2025
Department of Intensive Care Unit, General Hospital of Southern Theatre Command of PLA, Guangzhou, China.
Multi-trauma presents significant challenges due to the complexity of injuries and high mortality rates. Early identification and intervention are crucial for improving outcomes in these critically injured patients. This retrospective study analyzed clinical data from multi-trauma patients admitted to the emergency department of Huiyang Sanhe Hospital between January 10, 2020, and September 30, 2022.
View Article and Find Full Text PDFBiomolecules
December 2024
Department of Chemical Carcinogenesis, Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center for Oncology, Kashirskoe Shosse 24-15, Moscow 115478, Russia.
Glucocorticoids (GCs) are routinely used to treat hematological malignancies; however, long-term treatment with GCs can lead to atrophic and metabolic adverse effects. Selective glucocorticoid receptor agonists (SEGRAs) with reduced side effects may act as a superior alternative to GCs. More than 30 SEGRAs have been described so far, yet none of them reached clinical trials for anti-cancer treatment.
View Article and Find Full Text PDFBiomedicines
December 2024
EuroEchoLab, Craiova Cardiology Center, Emergency Hospital Craiova, 200642 Craiova, Romania.
Background/objectives: This study aimed to evaluate layer-specific strain according to etiology and assess whether subtle changes in longitudinal and circumferential layer strain are involved in predicting cardiac mortality during a two-year follow-up in patients with dilated cardiomyopathy admitted with heart failure decompensation.
Methods: 97 patients with dilated cardiomyopathy and a left ventricle ejection fraction ≤ 40% were recruited, 51 with ischemic and 46 with nonischemic etiologies. Conventional and two-dimensional speckle-tracking echocardiography (2D-STE) were conducted in dilated cardiomyopathy patients with a compensated phase of heart failure before discharge.
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