Donor PTX3 polymorphisms were shown to influence the risk of invasive aspergillosis among hematopoietic stem cell transplant recipients. Here, we show that PTX3 polymorphisms are independent risk factors for invasive mold infections among 1101 solid organ transplant recipients, thereby strengthening their role in mold infection pathogenesis and patients' risk stratification.
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| http://dx.doi.org/10.1093/cid/civ386 | DOI Listing |
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A study of granulysin and pentraxin 3 genetic polymorphisms and their contribution to acne susceptibility.
Arch Dermatol Res
October 2024
Dermatology and Andrology Department, Dekernes General Hospital, Dakahlia Governorate, Egypt.
Article Synopsis
- - This study investigates genetic variations in the GNLY and PTX3 genes and their link to acne in Egyptian individuals, highlighting the inflammatory nature of acne as a skin disorder.
- - The research included 180 acne patients and 180 healthy controls, using real-time PCR to analyze specific genetic polymorphisms (SNPs) related to these genes.
- - Results showed that the PTX3 rs2305619 variant is significantly associated with acne susceptibility, indicating that individuals with certain genotypes (AG + GG) are more likely to develop acne, while the GNLY rs7908 polymorphism does not show a similar association.
Functional variants of the pentraxin 3 gene are associated with the metastasis and progression of prostate cancer.
J Cell Mol Med
August 2024
Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Age, ethnic background and genetic components have been identified as the established risks for prostate cancer (PCa). Pentraxin 3 (PTX3), originally identified as a pattern-recognition molecule for defence against infectious agents, has multiple functions in tissue repair and in the regulation of cancer-associated inflammation. In this study, we sought to investigate the impact of PTX3 gene variants on the development of PCa.
View Article and Find Full Text PDFThe Impact of Pentraxin 3 Serum Levels and Angiotensin-Converting Enzyme Polymorphism on Pulmonary Infiltrates and Mortality in COVID-19 Patients.
Biomedicines
July 2024
Medical Faculty Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia.
Objectives: The aim of this study was to examine the impact of the pentraxin 3 (PTX3) serum level and angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism on the severity of radiographic pulmonary infiltrates and the clinical outcomes of COVID-19.
Methods: The severity of COVID-19 pulmonary infiltrates was evaluated within a week of admission by analyzing chest X-rays (CXR) using the modified Brixia (MBrixa) scoring system. The insertion (I)/deletion (D) polymorphism of the gene and the serum levels of PTX3 were determined for all patients included in the study.
Validating genetic variants in innate immunity linked to infectious events in acute myeloid leukemia post-induction chemotherapy.
Genes Immun
August 2024
Klinik für Innere Medizin II, Abteilung für Hämatologie und Internistische Onkologie, Comprehensive Cancer Center Central Germany - Campus Jena, Universitätsklinikum Jena, Jena, Germany.
Article Synopsis
- * This study aimed to validate the role of 11 specific SNPs across 6 immune-related genes in the susceptibility to infections using two independent cohorts of AML patients undergoing chemotherapy.
- * Findings revealed that certain SNPs, particularly in the DC-SIGN gene, were significantly associated with sepsis across both cohorts, while other genes like PTX3 and Dectin-1 showed links to invasive fungal disease in individual cohorts, highlighting the importance of genetic factors in managing infections in AML patients. *
Interleukin-1β Polymorphisms Are Genetic Markers of Susceptibility to Periprosthetic Joint Infection in Total Hip and Knee Arthroplasty.
Genes (Basel)
May 2024
IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.
Periprosthetic joint infections (PJIs) are serious complications of prosthetic surgery. The criteria for the diagnosis of PJI integrate clinical and laboratory findings in a complex and sometimes inconclusive workflow. Host immune factors hold potential as diagnostic biomarkers in bone and joint infections.
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