Hot punching with two different strategies has been demonstrated as a new method of fabricating high aspect ratio 3D microstructures for drug delivery. It has been shown that this process is highly versatile with good replication fidelity and yield.
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Patterning and nanoribbon formation in graphene by hot punching.
Nanotechnology
January 2025
Department of Physics (DTU Fysik), Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark.
Article Synopsis
- Current graphene patterning techniques like electron beam lithography and nano imprint lithography are slow and less effective for larger samples, often resulting in rough edges and misalignment.
- This study introduces hot punching as a new and efficient method for patterning CVD graphene sheets supported by a PVA layer, allowing for the creation of nanoribbons.
- The effects of hot punching on the graphene are analyzed through various methods, showing improvements such as aligned and smoother edges, along with the occurrence of wrinkling and strain.
Optimizing critical quality attributes of fast disintegrating tablets using artificial neural networks: a scientific benchmark study.
Drug Dev Ind Pharm
December 2024
Department of Pharmaceutical Technology, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology (CHARUSAT), CHARUSAT Campus, Changa, Gujarat, India.
Objective: The objective of this study is to create predictive models utilizing machine learning algorithms, including Artificial Neural Networks (ANN), k-nearest neighbor (kNN), support vector machines (SVM), and linear regression, to predict critical quality attributes (CQAs) such as hardness, friability, and disintegration time of fast disintegrating tablets (FDTs).
Methods: A dataset of 864 batches of FDTs was generated by varying binder types and amounts, disintegrants, diluents, punch sizes, and compression forces. Preprocessing steps included normalizing numerical features based on industry standards, one-hot encoding for categorical variables, and addressing outliers to ensure data consistency.
Enhancing productivity through work study - A case of electric power pole cross arm fabrication.
Heliyon
June 2024
Mechanical Engineering Program, Faculty of Mechanical and Industrial Engineering, Institute of Technology, Bahir Dar University, Ethiopia.
In the area of globalization any manufacturing industry must be competent in terms of productivity, quality, cost and delivery. A fundamental improvement in production is necessary to succeed in the international markets. Work study is one of the earliest scientific management methods used to determine the best way to perform production tasks in order to reduce idle time and worker fatigue as a result, increase productivity.
View Article and Find Full Text PDFThe Effects of Hot Isostatic Pressing (HIP) and Heat Treatment on the Microstructure and Mechanical Behavior of Electron Beam-Melted (EBM) Ti-6Al-4V Alloy and Its Susceptibility to Hydrogen.
Materials (Basel)
June 2024
Department of Materials Science and Engineering, Tel-Aviv University, Tel Aviv 6997801, Israel.
The effects of the secondary processes of Hot Isostatic Pressing (HIP) at 920 °C and Heat Treatment (HT) at 1000 °C of Electron Beam-Melted (EBM) Ti-6Al-4V alloy on the microstructure and hydrogen embrittlement (HE) after electrochemical hydrogen charging (EC) were investigated. Comprehensive characterization, including microstructural analysis, X-ray diffraction (XRD), thermal desorption analysis, and mechanical testing, was conducted. After HIP, the β-phase morphology changed from discontinuous Widmanstätten to a more continuous structure, 10 times and ~1.
View Article and Find Full Text PDFLeakage and Thermal Reliability Optimization of Stacked Nanosheet Field-Effect Transistors with SiC Layers.
Micromachines (Basel)
March 2024
School of Microelectronics, Xidian University, Xi'an 710071, China.
In this work, we propose a SiC-NSFET structure that uses a PTS scheme only under the gate, with SiC layers under the source and drain, to improve the leakage current and thermal reliability. Punch-through stopper (PTS) doping is widely used to suppress the leakage current, but aggressively high PTS doping will cause additional band-to-band (BTBT) current. Therefore, the bottom oxide isolation nanosheet field-effect transistor (BOX-NSFET) can further reduce the leakage current and become an alternative to conventional structures with PTS.
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