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Targeting RNA splicing modulation: new perspectives for anticancer strategy?
J Exp Clin Cancer Res
January 2025
Department of Pharmacology, School of Pharmacy, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning Province, 110122, P. R. China.
The excision of introns from pre-mRNA is a crucial process in the expression of the majority of genes. Alternative splicing allows a single gene to generate diverse mRNA and protein products. Aberrant RNA splicing is recognized as a molecular characteristic present in almost all types of tumors.
View Article and Find Full Text PDFDrug-related macular edema: a real-world FDA Adverse Event Reporting System database study.
BMC Pharmacol Toxicol
January 2025
Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, 201399, China.
Purpose: This study aims to assess the risks associated with drug-induced macular edema and to examine the epidemiological characteristics of this condition.
Methods: This study analyzed data from the U.S.
The effects of aerobic exercise on goal-directed attention and inhibitory control in individuals with high trait anxiety: an EEG study.
BMC Psychol
January 2025
Faculty of Psychology, Naval Medical University, Shanghai, China.
Anxiety is known to significantly impair cognitive function, particularly attentional control. While exercise has been demonstrated to alleviate these cognitive deficits, the precise neural mechanisms underlying these effects remain poorly understood. This study examines the effects of exercise on attentional control in individuals with high trait anxiety, based on attentional control theory, which suggests that such individuals have reduced top-down attention.
View Article and Find Full Text PDFSuperficial arteriovenous malformations are rare fast-flow lesions. They consist of arteriovenous shunts, without cellular hyperplasia or proliferation, which develop in the surrounding tissues (cutaneous, subcutaneous, muscular, bone). Although benign, they are among the most severe of superficial malformations.
View Article and Find Full Text PDFAirway morphology, hyoid position, and serum inflammatory markers of obstructive sleep apnea in children treated with modified twin-block appliances.
BMC Oral Health
January 2025
The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing, 400016, P.R. China.
Objective: To investigate the effects of modified twin-block appliances (MTBA) on obstructive sleep apnea (OSA) and mandibular retrognathia and the changes in the upper airway, hyoid bone position, and hypoxia-related inflammatory marker levels in children with OSA.
Methods: This study included children with OSA and mandibular retrognathia and those with class I without mandibular retrognathia (n = 35 each). The experimental group comprised children with OSA and mandibular retrognathia managed using MTBA.
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