[Magnetic resonance spectroscopy in lenticular nucleus of Bipolar II disorder and its relation with cognitive function].

Objective: To explore the magnetic resonance spectroscopy characteristics of lenticular nucleus in Bipolar II disorder and its relation with cognitive function.

Methods: Thirty Bipolar II disorder patients in hospital from 2012 September to 2013 April and twenty healthy controls were evaluated with Multi-Voxel 1H-MRS scans on lenticular nucleus to assess the NAA, Cho, Cr and MI. All subjects were assessed for attention using the Stroop Test and executive function by Wisconsin card sorting test.

Results: NAA, Cho, Cr in right lenticular nucleus and Cr in left lenticular nucleus were lower than healthy controls (P < 0.05). The patients showed significant cognitive impairment in all aspects of Stroop Test and Wisconsin card sorting test (P < 0.05). NAA in right lenticular nucleus was positively correlated with correct number of Stroop-CW.

Conclusions: Neural dysfunction in right lenticular nucleus of Bipolar II disorder may influence attention function. Cellular energy metabolism rate was reduced in bilateral lenticular nucleus.