AI Article Synopsis
- The study aimed to find a link between the Q63R variant of the cannabinoid 2 (CB2) receptor and its role in juvenile idiopathic arthritis (JIA).
- Researchers analyzed 171 children with JIA and 600 healthy controls, discovering a significant difference in the CB2 Q63R variant's distribution between the groups.
- The findings suggest that the R63 variant is associated with a higher risk of disease relapse and indicates that the CB2 receptor may influence both susceptibility and severity of oligo/polyarticular JIA.
Article Abstract
Objectives: To investigate whether the functional variant Q63R of the cannabinoid 2 (CB2) receptor is associated with susceptibility to oligo/poly-articular juvenile idiopathic arthritis (JIA) and with its clinical features.
Method: A total of 171 Italian children with oligoarticular/rheumatoid factor negative poly-articular JIA and 600 healthy controls were enrolled in the study and genotyped.
Results: A significant difference in genotype distribution of the CB2 Q63R variant (CNR2 rs35761398) between oligo/poly-articular JIA patients and controls was found (p = 0.001). The R63 variant was associated with increased rates of relapse (p = 0.0001).
Conclusions: This study indicates that the CB2 receptor contributes to susceptibility to oligo/polyarticular JIA and to the severity of its clinical course.
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| http://dx.doi.org/10.3109/03009742.2015.1020863 | DOI Listing |
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