Heterocycle-containing macrocycles are an emerging class of molecules that have therapeutic efficacy. Many biologically active natural products that have interesting biological properties fall into this class of molecules. The highly specific and selective biological activity is often attributed to the unique conformation of these macrocycles, which is affected by the elements of the macrocycles as well as its surroundings in biological systems. In this review, the structure-activity relationship studies of several recently developed biologically active heterocycle-containing macrocycles have been discussed in order to facilitate an understanding on how unpredictable structures can be controlled.
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Département de Pharmacologie-Physiologie, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, 3001 12e ave Nord, Sherbrooke, QC J1H5N4, Canada.
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Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.
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National Institute of Science Education and Research Bhubaneswar, P.O. Jatni, Khurda 752050, Odisha, India.
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Department of Chemistry and Biochemistry , University of Arizona , 1306 E. University Boulevard, Tucson , Arizona 85721 , United States.
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