Multifocal Micronodular Pneumocyte Hyperplasia (MMPH) is a rare and histologically, distinctive pulmonary manifestation of tuberous sclerosis complex (TSC) characterized by numerous and extensive proliferative lesions of type II pneumocytes similar to atypical adenomatous hyperplasia (AAH) or non-mucinous adenocarcinoma in situ (AIS). We reported MMPH in a 38-year-old Chinese man with TSC masquerading for 16 months as miliary tuberculosis and discussed the differential diagnosis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396337 | PMC |
Publication Analysis
Top Keywords
Similar Publications
A Comparison of Clinical and Radiological Presentations of Sporadic and Tuberous Sclerosis Complex-Associated Lymphangioleiomyomatosis.
Am J Med Genet A
January 2025
Massachusetts General Hospital, Boston, Massachusetts, USA.
Article Synopsis
- - This study compares the clinical and radiological features of tuberous sclerosis complex (TSC)-associated lymphangioleiomyomatosis (LAM) and sporadic LAM by reviewing medical records of 90 confirmed cases.
- - Patients with sporadic LAM showed more clinical symptoms at diagnosis, while TSC-LAM patients presented all four analyzed CT phenotypes, including multiple sclerotic bone lesions and fat-containing lesions in various organs.
- - The findings indicate significant differences between the two LAM types, which could lead to updated diagnostic criteria, while also highlighting similarities that may help understand the underlying mechanisms of sporadic LAM.
Tuberous sclerosis complex: A clinical diagnosis in Ethiopian patients.
Medicine (Baltimore)
February 2024
Department of Radiology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Article Synopsis
- - Tuberous sclerosis complex (TSC) is a rare genetic disorder causing nonmalignant growths in various organs, with delayed diagnosis often resulting from a lack of physician familiarity.
- - Two patients, a 27-year-old man with kidney issues and a 28-year-old woman with seizures, were diagnosed with TSC through established diagnostic criteria and exhibited various skin lesions.
- - Both patients were advised to receive ongoing care: the male was referred to a chronic illness clinic, while the female was scheduled for dermatological treatment for her facial lesions.
Multiple Micronodular Pneumocyte Hyperplasia (MMPH): A Less-Known Presentation of Tuberous Sclerosis Complex Related Lung Disease.
J Belg Soc Radiol
April 2023
UZ Leuven, BE.
Multiple micronodular pneumocyte hyperplasia (MMPH) is a less-known presentation of tuberous sclerosis complex (TSC) associated lung disease that usually requires no treatment or follow-up imaging.
View Article and Find Full Text PDFDifficulties in Differentiating Osteosclerosis in Patients With Multifocal Micronodular Pneumocyte Hyperplasia and Cancer.
Cureus
March 2023
Department of Respiratory Medicine, Nara Medical University, Kashihara, JPN.
A 52-year-old woman with multifocal micronodular pneumocyte hyperplasia in bilateral lungs and multiple sclerotic bone lesions (SBLs) visited our hospital. Tuberous sclerosis complex (TSC) was suspected but did not meet the diagnostic criteria. Ten years later, at age 62, the patient developed ureteral cancer.
View Article and Find Full Text PDFPrevalence of thoracoabdominal imaging findings in tuberous sclerosis complex.
Orphanet J Rare Dis
March 2022
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Background: Tuberous sclerosis complex (TSC) results in neurodevelopmental phenotypes, benign tumors, and cysts throughout the body. Recent studies show numerous rare findings in TSC. Guidelines suggest routine abdominal and chest imaging to monitor these thoracoabdominal findings, but imaging is not uniformly done across centers.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!