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Ebselen as a potent covalent inhibitor of New Delhi metallo-β-lactamase (NDM-1). | LitMetric
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Ebselen as a potent covalent inhibitor of New Delhi metallo-β-lactamase (NDM-1).

Jiachi Chiou Shengbiao Wan Kin-Fai Chan Pui-Kin So Dandan He Edward Wai-chi Chan Tak-hang Chan Kwok-yin Wong Jiang Tao Sheng Chen

Chem Commun (Camb)

Shenzhen Key Laboratory for Food Biological Safety Control, Food Safety and Technology Research Centre, The Hong Kong Polytechnic University, Shenzhen Research Institute, Shenzhen, P.R. China.

Published: June 2015

We report the discovery of a promising NDM-1 inhibitor, ebselen, through a cell-based screening approach. Enzymatic kinetic study and ESI-MS analysis suggested that ebselen could bind to NDM-1 by forming a S-Se bond with the Cys(221) residue at the active site, thereby exhibiting a new inhibition mechanism with broad spectrum inhibitory potential.

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 Source
http://dx.doi.org/10.1039/c5cc02594jDOI Listing

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