Toxic epidermal necrolysis induced by methazolamide in a Chinese-Korean man carrying HLA-B*59:01.

Background: Methazolamide is used to lower intraocular pressure in patients with glaucoma. Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) associated with methazolamide treatment have been diagnosed in Korean, Japanese, and Japanese-American patients. According to recent research, the human leukocyte antigen (HLA) allele HLA-B*59:01 is strongly linked to SJS/TEN associated with methazolamide treatment.

Objective: A patient of Chinese-Korean ethnicity was diagnosed with TEN associated with methazolamide treatment. The purpose of this study was to examine the potential genetic basis of this disease.

Methods: A polymerase chain reaction sequence-specific primer (PCR-SSP) typing system was used to genotype this patient's peripheral blood DNA for HLA-B*59.

Results: The genotype HLA-B*59:01 was detected in the patient.

Conclusions: This study demonstrates the genotype of HLA-B*59:01 in a patient with TEN associated with methazolamide treatment and thus supports the possible correlation between genetic background and methazolamide-associated SJS/TEN.