Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Host defense against oral microbiota by bone-damaging T cells.
Nat Commun
February 2018
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, 113-0033, Tokyo, Japan.
The immune system evolved to efficiently eradicate invading bacteria and terminate inflammation through balancing inflammatory and regulatory T-cell responses. In autoimmune arthritis, pathogenic T17 cells induce bone destruction and autoimmune inflammation. However, whether a beneficial function of T-cell-induced bone damage exists is unclear.
View Article and Find Full Text PDF[Medicine--the double-edged sword].
Ugeskr Laeger
May 2015
Geriatrisk Afdeling, Odense Universitetshospital, Sdr. Boulevard 29, 5000 Odense C.
How to leverage an endogenous immune defense mechanism: the example of granulocyte colony-stimulating factor.
Crit Care Med
January 2003
Biochemical Pharmacology, University of Konstanz, Konstanz, Germany.
Our understanding of host defense has exploded during the past two decades. It is temping to take advantage of this knowledge by considering the modulation and control of these mechanisms as therapeutic options. In intensive care medicine, the aim is usually to block an overwhelming inflammatory response, which represents the "bad" side of the double-edged sword of host defense.
View Article and Find Full Text PDFChronic lung disease: oxygen dogma revisited.
Acta Paediatr
February 2001
Department of Pediatric Research, The National Hospital, University of Oslo, Norway.
Since the discovery of retrolental fibroplasia, and the role of oxygen in its development, oxygen has been considered a double-edged sword in neonatal medicine, the utmost care being exercised in order not to give too much oxygen (1). However, the important observation that hypoxaemia might induce pulmonary vasoconstriction (2) and airway constriction (3) in infants at risk for bronchopulmonary dysplasia has resulted in only a minor upward adjustment of oxygen supplementation in many neonatal units. Since oxygen toxicity has long been linked not only to retinopathy of prematurity but also to bronchopulmonary dysplasia (4), it is relevant to ask whether an increased FiO2 might have any detrimental effects on babies.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!