AI Article Synopsis
- - Traumatic brain injury leads to ongoing brain shrinkage and cognitive issues over time.
- - Early treatment with erythropoietin (EPO) can prevent these negative effects, although how it works has not been clear until now.
- - New imaging techniques reveal that EPO reduces microglial activity, which are immune cells in the brain, thus decreasing their movement in response to injury.
Article Abstract
Traumatic brain injury causes progressive brain atrophy and cognitive decline. Surprisingly, an early treatment with erythropoietin (EPO) prevents these consequences of secondary neurodegeneration, but the mechanisms have remained obscure. Here we show by advanced imaging and innovative analytical tools that recombinant human EPO, a clinically established and neuroprotective growth factor, dampens microglial activity, as visualized also in vivo by a strongly attenuated injury-induced cellular motility.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527993 | PMC |
| http://dx.doi.org/10.1038/jcbfm.2015.100 | DOI Listing |
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