Resting state functional Magnetic Resonance Imaging (rs-fMRI) is increasingly used for the identification of image biomarkers of brain diseases or psychiatric conditions such as schizophrenia. This paper deals with the application of ensembles of Extreme Learning Machines (ELM) to build Computer Aided Diagnosis systems on the basis of features extracted from the activity measures computed over rs-fMRI data. The power of ELM to provide quick but near optimal solutions to the training of Single Layer Feedforward Networks (SLFN) allows extensive exploration of discriminative power of feature spaces in affordable time with off-the-shelf computational resources. Exploration is performed in this paper by an evolutionary search approach that has found functional activity map features allowing to achieve quite successful classification experiments, providing biologically plausible voxel-site localizations.
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http://dx.doi.org/10.1016/j.neunet.2015.04.002 | DOI Listing |
Oper Dent
January 2025
Nathaniel C Lawson, DDS, PhD, director of Master of Science in Dental Biomaterials program and associate professor, Department of Clinical and Community Sciences, University of Alabama at Birmingham School of Dentistry, Birmingham, AL, USA.
Objective: This study aimed to assess the fracture resistance of chairside computer assisted design and computer assisted manufacturing (CAD-CAM) lithium disilicate partial and full-coverage crowns and veneers for maxillary canines.
Methods And Materials: Forty-eight restorations for maxillary right canines (12 per group) were designed as follows: (1) partial crown with finish line in the upper middle third; (2) partial crown with finish line in the lower middle third; (3) traditional labial veneer; and (4) traditional full-coverage crown. Restorations were fabricated out of lithium disilicate (Amber Mill, Hassbio) using a chairside CAD-CAM system (Cerec Dentsply Sirona).
Oper Dent
January 2025
*Kraig S. Vandewalle, DDS, MS, Col (ret), USAF, DC, Air Force Consultant in Dental Research Advanced Education in General Dentistry Residency, AF Postgraduate Dental School, Joint Base San Antonio - Lackland, TX, USA; Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Objective: The purpose of this study was to compare the optical, mechanical, and biological properties of two new, inexpensive lithium disilicate (LS2) materials (Lodden (LOD), LD Medical Technology; and BeautyZir (BZ), BeautyZir Technology) to a clinically established LS2 material (IPS e.max CAD (EMAX), Ivoclar Vivadent).
Methods And Materials: The optical properties of the translucency parameter (TP) and opalescence parameter (OP) were obtained with a dental spectrophotometer.
Mol Carcinog
January 2025
Key Laboratory of Computer-Aided Drug Design of Dongguan City, The First Dongguan Affiliated Hospital, School of Pharmacy, Guangdong Medical University, Dongguan, Guangdong, China.
The progression of tumors has been demonstrated to have a strong correlation with ferroptosis. Bis(4-hydroxy-3,5-dimethylphenyl) sulfone (TMBPS) has been shown to effectively inhibit the proliferation of hepatocellular carcinoma (HCC), but its underlying mechanism is not clear. In this study, ferrostatin-1 (Fer-1) was employed to explore whether the death of HCC cells caused by TMBPS is related to ferroptosis.
View Article and Find Full Text PDFJ Imaging Inform Med
January 2025
Laboratory of Computing, Medical Informatics and Biomedical Imaging Technologies, School of Medicine, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece.
A scoping review was conducted to investigate the role of radiological imaging, particularly high-resolution computed tomography (HRCT), and artificial intelligence (AI) in diagnosing and prognosticating idiopathic pulmonary fibrosis (IPF). Relevant studies from the PubMed database were selected based on predefined inclusion and exclusion criteria. Two reviewers assessed study quality and analyzed data, estimating heterogeneity and publication bias.
View Article and Find Full Text PDFSci Rep
January 2025
School of BioSciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, 632014, India.
The proliferation-specific oncogenic transcription factor, FOXM1 is overexpressed in primary and recurrent breast tumors across all breast cancer (BC) subtypes. Intriguingly, FOXM1 overexpression was found to be highest in Triple-negative breast cancer (TNBC), the most aggressive BC with the worst prognosis. However, FOXM1-mediated TNBC pathogenesis is not completely elucidated.
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