AI Article Synopsis
- Nitraria retusa is a salt-tolerant plant found in North Africa, recognized for its traditional medicinal uses.
- The study shows that the ethanol extract of N. retusa and its component isorhamnetin (IRA) were effective in preventing cell damage caused by amyloid β (Aβ) in human neuroblastoma cells.
- Additionally, tests indicated that IRA disrupts the formation of Aβ fibrils, which are associated with neurodegenerative diseases.
Article Abstract
Nitraria retusa is a halophyte species that is distributed in North Africa and used as a traditional medicinal plant. In this study, N. retusa ethanol extract and its constituent isorhamnetin (IRA) protected against amyloid β (Aβ)-induced cytotoxicity in human neuroblastoma SH-SY5Y cells. An in vitro Aβ aggregation assay suggested that IRA destabilizes Aβ fibrils.
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| http://dx.doi.org/10.1080/09168451.2015.1027655 | DOI Listing |
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