AI Article Synopsis
- The use of selective serotonin reuptake inhibitors (SSRIs), like sertraline, can lead to mild to severe spontaneous bleeding, although the exact cause is unclear.
- A case report highlights a 44-year-old woman with anxiety disorder who experienced periorbital purpura while on sertraline, suggesting a potential connection between SSRIs and bleeding risks.
- To mitigate these risks, it's suggested that non-SSRI alternatives should be considered for treatment, and further research is necessary to explore SSRIs' impact on bleeding and hemostasis.
Article Abstract
Objective: The incidence of mild to severe levels of spontaneous bleeding due to the usage of selective serotonin reuptake inhibitors (SSRIs) is relatively low. Although the exact mechanism is not known, it is thought that inhibition of the serotonin transporter together with a decrease in platelet serotonin could be responsible for the bleeding. Therefore, the use of SSRIs in conjunction with anti-aggregants may predispose to or exacerbate the risk of bleeding. In this case report, we describe a 44-year-old female patient with a diagnosis of anxiety disorder who spontaneously developed periorbital purpura during treatment with sertraline.
Conclusion: Abnormal bleeding after treatment with an SSRI should be kept in mind, and alternative non-SSRI drugs of choice in such cases would be more appropriate. More extensive and comprehensive studies focusing on hemostasis and bleeding disorders are needed for SSRIs such as sertraline.
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| http://dx.doi.org/10.1177/1039856215586138 | DOI Listing |
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