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Inopinatus corneliae sp. nov. gen. nov. isolated from human skin: A newly discovered keratinophilic hyphomycete, order Onygenales.
Mycoses
August 2024
Leibniz Institute DSMZ, German Collection of Microorganisms and Cell Cultures GmbH, Braunschweig, Germany.
Background: Fungi clinically relevant to human skin comprise prevalent commensals and well-known pathogens. Only rarely human skin harbours fungi that evade identification.
Objective: To characterise an enigmatic specimen isolated from a skin lesion.
Human Leukocyte Antigen Genotyping of Idiopathic Subglottic Stenosis.
Laryngoscope
October 2023
Department of Otolaryngology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Objective: Despite recent scientific inquiry, idiopathic subglottic stenosis (iSGS) remains an enigmatic disease. The consistent demographics of the affected population suggest genetic factors may contribute to disease susceptibility. Given the inflammation observed in the affected proximal airway mucosa, we interrogated disease association with human leukocyte antigen (HLA) polymorphisms.
View Article and Find Full Text PDFMacrophage migration inhibitory factor in Nodding syndrome.
PLoS Negl Trop Dis
October 2021
Goldyne Savad Institute of Gene Therapy, Hadassah Medical Organization and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Article Synopsis
- - Nodding syndrome (NS) is a severe childhood epilepsy linked to autoimmune processes and caused primarily by the parasitic worm Onchocerca Volvulus, linked to blackfly bites.
- - Recent research indicates that certain genetic factors, including MIF gene polymorphisms and HLA associations, play a role in NS susceptibility and protection, with high-expression MIF potentially providing a protective effect.
- - Although the presence of the MIF gene variant indicates possible protection, elevated plasma MIF levels in NS patients suggest it may also contribute to harmful autoimmunity and neuroinflammation.
The molecular phylogeny of Chionaster nivalis reveals a novel order of psychrophilic and globally distributed Tremellomycetes (Fungi, Basidiomycota).
PLoS One
September 2021
Department of Botany, University of British Columbia, Vancouver, British Columbia, Canada.
Snow and ice present challenging substrates for cellular growth, yet microbial snow communities not only exist, but are diverse and ecologically impactful. These communities are dominated by green algae, but additional organisms, such as fungi, are also abundant and may be important for nutrient cycling, syntrophic interactions, and community structure in general. However, little is known about these non-algal community members, including their taxonomic affiliations.
View Article and Find Full Text PDFWide distribution of Phycisphaera-like planctomycetes from WD2101 soil group in peatlands and genome analysis of the first cultivated representative.
Environ Microbiol
March 2021
Institute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow, Russia.
Phycisphaera-like WD2101 'soil group' is one of the as-yet-uncultivated phylogenetic clades within the phylum Planctomycetes. Members of this clade are commonly detected in various terrestrial habitats. This study shows that WD2101 represented one of the major planctomycete groups in 10 boreal peatlands, comprising up to 76% and 36% of all Planctomycetes-affiliated 16S rRNA gene reads in raised bogs and eutrophic fens respectively.
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