AI Article Synopsis
- Menin, encoded by the MEN1 gene, is identified as a tumor suppressor and is shown to enhance PPARα activity, reducing triglyceride buildup in the liver.
- Menin inhibits the transcriptional activity of liver X receptor α (LXRα), leading to decreased expression of genes associated with fat production, such as SREBP-1c, FASN, and SCD-1.
- The study suggests Menin acts as a corepressor of LXRα, playing a key role in negatively regulating fat production in the liver.
Article Abstract
Menin, encoded by the MEN1 gene, was initially identified as a tumor suppressor for endocrine neoplasia. Our previous report showed that Menin enhances PPARα transactivity preventing triglyceride accumulation in the liver. Here, we further explore the role of Menin in liver steatosis. Transient transfection assays demonstrate that Menin inhibits the transcriptional activity of nuclear receptor liver X receptor α (LXRα). Accordingly, Menin overexpression results in reduced expression of LXRα target genes, such as lipogenic enzymes including SREBP-1c, FASN and SCD-1. Co-immunoprecipitation assays revealed physical interaction between Menin and LXRα. Collectively, our data suggest that Menin acts as a novel corepressor of LXRα and functions as a negative regulator of hepatic lipogenesis.
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| http://dx.doi.org/10.1016/j.febslet.2015.04.049 | DOI Listing |
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