The desymmetrization of -quinols using a Brønsted acid catalyzed acetalization/Michael cascade was achieved in high yields and diastereoselectivities for aldehydes and imines. Use of a chiral Brønsted acid allowed for the synthesis of 1,3-dioxolane and 1,3-oxazolidine products in modest enantioselectivity.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422513 | PMC |
| http://dx.doi.org/10.1055/s-0033-1340669 | DOI Listing |
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