Late Reactivation of Cherubism in a Patient With New-Onset Polycystic Ovary Syndrome.

Purpose: The aim of the present study was to describe a case of cherubism with late progression, after skeletal maturity had been reached, that coincided with a recent diagnosis of polycystic ovary syndrome (PCOS).

Patients And Methods: We reviewed the published data and searched for any reported association between cherubism and PCOS. We also reviewed the cases of late reactivation of cherubism.

Results: This is, to our knowledge, the first case report of cherubism associated with PCOS.

Conclusion: Cherubism is a rare condition, which, in its normal course, becomes quiescent after puberty. Only a few cases of late growth have been reported. The understanding of the condition has evolved in recent years, with a better appreciation of the underlying genetics and pathogenesis of the disease. However, much remains unknown about this rare entity. We describe a case of cherubism reactivation that coincided with changes related to PCOS. Both PCOS and cherubism are associated with a low-grade inflammatory state.