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| http://dx.doi.org/10.17269/cjph.106.4914 | DOI Listing |
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Exome sequencing identifies protein-coding variants associated with loneliness and social isolation.
J Affect Disord
January 2025
Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China. Electronic address:
Background: Loneliness and social isolation are serious yet underappreciated public health problems, with their genetic underpinnings remaining largely unknown. We aimed to explore the role of protein-coding variants in the manifestation of loneliness and social isolation.
Methods: We conducted the first exome-wide association analysis on loneliness and social isolation, utilizing 336,115 participants of white-British ancestry for loneliness and 346,115 for social isolation.
Wildland fire entrainment: The missing link between wildland fire and its environment.
PNAS Nexus
January 2025
Southern Research Station, US Forest Service, 320 Green Street, Athens, GA 30602, USA.
Wildfires are growing in destructive power, and accurately predicting the spread and intensity of wildland fire is essential for managing ecological and societal impacts. No current operational models used for fire behavior prediction resolve critical fire-atmospheric coupling or nonlocal influences of the fire environment, rendering them inadequate in accounting for the range of wildland fire behavior scenarios under increasingly novel fuel and climate conditions. Here, we present a new perspective on a dominant fire-atmospheric feedback mechanism, which we term wildland fire entrainment (WFE).
View Article and Find Full Text PDFEthics of Procuring and Using Organs or Tissue from Infants and Newborns for Transplantation, Research, or Commercial Purposes: Protocol for a Bioethics Scoping Review.
Wellcome Open Res
December 2024
National University of Singapore, Singapore, Singapore.
Unlabelled: Since the inception of transplantation, it has been crucial to ensure that organ or tissue donations are made with valid informed consent to avoid concerns about coercion or exploitation. This issue is particularly challenging when it comes to infants and younger children, insofar as they are unable to provide consent. Despite their vulnerability, infants' organs and tissues are considered valuable for biomedical purposes due to their size and unique properties.
View Article and Find Full Text PDFPrognostic nutritional index as a predictor of cardiovascular and all-cause mortality in American adults with hypertension: results from the NHANES database.
Front Cardiovasc Med
January 2025
State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Background: Few studies have examined the relationship between nutritional status, as assessed by the Prognostic Nutrition Index (PNI), and incident cardiovascular mortality and all-cause mortality, particularly in hypertensive patients. This study aimed to examine the association between PNI and cardiovascular mortality and all-cause mortality in Americans with hypertension.
Methods: Data from this retrospective cohort study were obtained from the National Health and Nutrition Examination (NHANES) 1999-2016.
NutriBase - management system for the integration and interoperability of food- and nutrition-related data and knowledge.
Front Nutr
January 2025
Computer Systems Department, Jožef Stefan Institute, Ljubljana, Slovenia.
Introduction: Contemporary data and knowledge management and exploration are challenging due to regular releases, updates, and different types and formats. In the food and nutrition domain, solutions for integrating such data and knowledge with respect to the FAIR (Findability, Accessibility, Interoperability, and Reusability) principles are still lacking.
Methods: To address this issue, we have developed a data and knowledge management system called NutriBase, which supports the compilation of a food composition database and its integration with evidence-based knowledge.
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