The purpose of this experiment was to examine when children identify their own experience as one of pride after they complete a difficult and competitive task (i.e., race a confederate in building a tower of blocks). A sample of 144 children between 3 and 6 years of age participated in one of three conditions. Children were told to try to build a tower of blocks taller than a confederate's tower (exceed standard) or tried and failed to build a tower of blocks taller than the confederate's tower (fail standard), or children were asked to build a tower of blocks alongside a confederate (no standard). Results revealed a developmental progression of recognizing pride in which children first began showing nonverbal behaviors that were reliably coded as conveying pride at around 4 years of age. Children began to apply the label/term "pride" to a photograph conveying pride in another peer at around 4 years of age and recognized their own experience as one of pride following a competitive task at around 5 years of age.
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http://dx.doi.org/10.1016/j.jecp.2015.03.010 | DOI Listing |
Psychoneuroendocrinology
January 2025
Women and Children's Medical Research Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. Electronic address:
Anxiety is one of the most common mental disorders. Neurotensin (NT) is a neuropeptide widely distributed in the central nervous system, involved in the pathophysiology of many neural and psychiatric disorders such as anxiety. However, the neural substrates mediating NT's effect on the regulation of anxiety have not been fully identified.
View Article and Find Full Text PDFDiagnostics (Basel)
December 2024
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, NUHS Tower Block Level 10, 1E Kent Ridge Road, Singapore 119228, Singapore.
Background: Endoscopic assessment for the diagnosis of gastric cancer is limited by interoperator variability and lack of real-time capability. Recently, Raman spectroscopy-based artificial intelligence (AI) has been proposed as a solution to overcome these limitations.
Objective: To compare the performance of the AI-enabled Raman spectroscopy with that of high-definition white light endoscopy (HD-WLE) for the risk classification of gastric lesions.
Immunotargets Ther
December 2024
Department of Thoracic Surgery, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing, 210008, People's Republic of China.
In recent years, the combination of immune checkpoint inhibitors (ICIs) with antiangiogenic agents has led to significant breakthroughs in cancer treatment. Such as programmed cell death 1 (PD-1), programmed cell death ligand 1 (PD-L1), and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4). Antiangiogenic therapy plays a pivotal role in normalizing blood vessels and remodeling the tumor immune microenvironment while ICIs not only enhance the host's antitumor immune response by blocking negative regulatory signals but also promote vascular normalization.
View Article and Find Full Text PDFBiomater Adv
January 2025
Department of Orthopaedic Surgery, National University of Singapore, NUHS Tower Block, Level 11, 1E Kent Ridge Road, Singapore 119228, Singapore.
Osteoporosis, characterized by reduced bone mineral density and increased fracture risk, poses a significant health challenge, particularly for aging populations. Systemic treatments often lead to adverse side effects, emphasizing the need for localized solutions. This study introduces a 3D-printed polycaprolactone (PCL) scaffold embedded with strontium-substituted mesoporous bioactive glass nanoparticles (Sr-MBGNPs) and icariin (ICN) for the targeted regeneration of osteoporotic bone.
View Article and Find Full Text PDFNat Commun
January 2025
The MOE Key Laboratory of Biosystems Homeostasis & Protection, Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, 310058, China.
Roles of liver-specific genes (LSGs) in tumor initiation and progression are rarely explored in hepatocellular carcinoma (HCC). Here we show that LSGs are generally downregulated in HCC tumor tissues compared to non-HCC liver tissues, and low-LSG HCCs show poor prognosis and the activated c-Myc pathway. Among the c-Myc- and patient prognosis-associated LSGs, PGRMC1 significantly blocks c-Myc-induced orthotopic HCC formation.
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