Objective: Our aim in this study was to determine the value of cervicovaginal cytology in surveillance for recurrent cervical cancer.
Materials And Methods: Charts were reviewed for 136 women with cervical cancer presenting at least 3 months after treatment with curative intent for a previously scheduled surveillance visit to Cook County Hospital between September 1, 1994, and December 31, 1995. Results of cytology and symptoms elicited by history and physical examination were compared to recurrences occurring within 6 months.
Results: Recurrences were identified in eight patients. Sites of recurrence included cervix-vaginal cuff (n = 5), pelvic wall (n = 1), and paraaortic or supraclavicular lymph nodes (n = 2). Sixteen women had symptoms, and seven had abnormal physical findings. One woman had malignant cytology. Sensitivity, specificity, and positive and negative predictive value were 38, 90, 23, and 96%, respectively, for symptoms; 50, 99, 80, and 97%, respectively, for examination; and 13, 100, 100, and 95%, respectively, for cytology.
Conclusion: After cervical cancer treatment, cervicovaginal cytology was a more specific but less sensitive predictor of recurrence within 6 months than were symptoms or physical findings.
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http://dx.doi.org/10.1097/00128360-199910000-00006 | DOI Listing |
Diseases
January 2025
Department of Speciality Disciplines, "Titu Maiorescu" University, 031593 Bucharest, Romania.
Cervical intraepithelial neoplasia (CIN) is a premalignant cervical condition closely linked to persistent high-risk HPV infection, a major risk factor for cervical cancer. This study aims to investigate the relationship between cervicovaginal infections, HPV infection, and CIN development in 94 Romanian women with cervical lesions. Comprehensive assessments included HPV genotyping, cytology, colposcopy, and histopathology.
View Article and Find Full Text PDFFront Oncol
January 2025
AO Vector-Best, Novosibirsk, Russia.
Background: Cervical screening, aimed at detecting precancerous lesions and preventing cancer, is based on cytology and HPV testing. Both methods have limitations, the main ones being the variable diagnostic sensitivity of cytology and the moderate specificity of HPV testing. Various molecular biomarkers are proposed in recent years to improve cervical cancer management, including a number of mRNAs encoded by human genes involved in carcinogenesis.
View Article and Find Full Text PDFJ Low Genit Tract Dis
January 2025
Division of Cancer Epidemiology & Genetics, National Cancer Institute, Rockville, MD.
Objective: The Enduring Consensus Cervical Cancer Screening and Management Guidelines Committee developed recommendations for the use of extended genotyping results in cervical cancer prevention programs.
Methods: Risks of cervical intraepithelial neoplasia grade 3 or worse were calculated using data obtained with the Onclarity HPV Assay from large cohorts. Management recommendations were based on clinical action thresholds developed for the 2019 American Society for Colposcopy and Cervical Pathology Risk-Based Management Consensus Guidelines.
AIDS Res Hum Retroviruses
January 2025
Servicio de Ginecología y Obstetricia, Hospital Universitario Torrecárdenas, GAEPI-VPH (Grupo Andaluz para el Estudio y la Prevención de la Infección por VPH), Almería, Spain.
Infection with Human immunodeficiency virus (HIV) shows a higher risk of infection by Human papillomavirus (HPV). We aim to provide evidence about the effect of a -based vaginal gel (Papilocare®) for treating HPV in women with HIV. Women ≥25 years coinfected by endocervical HPV and with low-grade abnormal cervicovaginal cytology were treated for 6 months with Papilocare® in this observational, prospective, non-controlled pilot study.
View Article and Find Full Text PDFJ Clin Med
December 2024
Federal State Budgetary Institution "National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov", Ministry of Healthcare of the Russian Federation, Oparina Street, Bld. 4, 117997 Moscow, Russia.
This review evaluates the advances in the early detection and diagnosis of endometrial cancer (EC), emphasizing the growing importance of minimally invasive techniques and novel biomarkers. Current diagnostic protocols for EC rely heavily on invasive procedures such as transvaginal ultrasound (TVU), hysteroscopy, and endometrial biopsy, which, although effective, can be overly burdensome for patients and inefficient for asymptomatic or low-risk populations. As there is no consensus on EC screening in high-risk or general populations, recent studies have explored alternative methods using biofluids and genomic biomarkers to improve sensitivity and specificity and facilitate access for patients.
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