Three experiments tested the prediction, derived from generalized frustration theory (Amsel, 1972), that habituation to behaviourally disruptive stimuli increases resistance to extinction in the runway. In each experiment, rats received initial consistent reinforcement (CRF) training and then either continued CRF (Groups C), partial reinforcement (PRF) training (Groups P), or CRF accompanied by presentations of a novel tactile, tone, or obstacle stimulus (Groups D) in Experiments 1-3, respectively. PRF increased resistance to extinction whether non-reinforcement disrupted behaviour (Experiment 1) or not (Experiments 2 and 3). The tactile and obstacle stimuli very substantially disrupted behaviour, and the tone produced a modest disruption of behaviour. All subjects habituated to the disruptive effects of these stimuli, but Group D was not more resistant to extinction than Group C in any experiment. The results suggest that non-reinforcement has unique stimulus properties, a consequence of which is that habituation to other sources of disruptive stimulation does not promote responding to non-reinforcement in extinction.
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Front Vet Sci
February 2025
Canine Performance Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL, United States.
Training detection dogs to alert to an odor requires precision in the timing and delivery of stimulus presentations in order to condition a strong association between odor and reward and to train a desired alert behavior that communicates the presence and location of the odor source. Marker training, in which a signal that predicts a reward is used to deliver immediate feedback for a correct response and bridge the delay between the desired behavior and reward, is a popular technique in the animal training industry. However, the application of marker training to detection dog training has not been examined, and empirical evidence of the purported benefits of marker training in general is lacking.
View Article and Find Full Text PDFSemin Fetal Neonatal Med
February 2025
University of Utah, College of Medicine, Department of Pediatrics, Division of Neonatology, 925 Chipeta Dr, Salt Lake City, 84108, UT, USA. Electronic address:
Nearly half a century ago, granulocyte transfusions were trialed in critically ill, septic, neutropenic neonates and showed improved survival when used concurrently with antimicrobials. Benefits were particularly noteworthy for Gram-negative and fungal infections. The introduction of granulocyte colony-stimulating factor into clinical medicine in 1991 and inherent problems associated with granulocyte procurement for transfusion caused granulocyte transfusions to become nearly extinct for this patient population.
View Article and Find Full Text PDFJ Am Acad Child Adolesc Psychiatry
February 2025
Icahn School of Medicine at Mount Sinai, New York, New York.
Objective: This randomized controlled study tested the effect of interoceptive exposure on anterior insula function and connectivity for the extinction of palatable and rotten food-cue associations in female adolescents with low weight eating disorders (LWED).
Method: Thirty-nine female adolescents with LWED and 19 matched controls performed a food-related conditioning paradigm during functional magnetic resonance imaging (fMRI). Adolescents with LWED were then randomized to six sessions of either interoceptive exposure (n = 18) or family-based (n = 21) treatment, followed by a second fMRI.
BMC Complement Med Ther
February 2025
International Centre for Infectious Diseases, Biosafety and Biosecurity Research, Department of Medical Biochemistry, David Umahi Federal University of Health Sciences, Uburu, Nigeria.
Background: Malaria is an infectious disease, which has continued to cause inconceivable loss of lives every year, almost unabatedly. Currently, it has become more difficult to treat the disease due to the emergence and spread of resistance to recommended antimalarial drugs. This situation necessitates an urgent search for antimalarial compounds with unique modes of action.
View Article and Find Full Text PDFTransl Psychiatry
February 2025
Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy.
Post-Traumatic Stress Disorder (PTSD) is a psychiatric disease that may develop after experiencing a traumatic event and it is characterized by resistance to extinction of the traumatic memory. Psychotherapy, which mainly focuses on favoring fear memory extinction, represents the first-line treatment for PTSD. However, this approach is not always successful.
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