Infection of human neurons in vitro with varicella-zoster virus (VZV) at a low multiplicity of infection does not result in a cytopathic effect (CPE) within 14 days postinfection (dpi), despite production of infectious virus. We showed that by 28 dpi a CPE ultimately developed in infected neurons and that interferon gamma inhibited not only the CPE but also VZV DNA accumulation, transcription, and virus production, thereby prolonging the life of VZV-infected neurons.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473560 | PMC |
| http://dx.doi.org/10.1128/JVI.00594-15 | DOI Listing |
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