In this work, we present a two-step method to controllably synthesize novel and highly efficient upconversion materials, Lu5O4F7:Er(3+),Yb(3+) nano/micro-crystals, and investigate their size/morphology induced tunable upconversion properties. In addition to the common phenomenon aroused by a surface quenching effect, direct experimental evidence for the regulation of phonon modes is obtained in nanoparticles. The findings in this work advance the existing mechanisms for the general explanation of size/morphology induced upconversion features. Because of the adjustment of phonon energy and density as well as the surface quenching effect, the biocompatible Lu5O4F7:Er(3+),Yb(3+) nanoparticles exhibit an ultra-strong single-band red upconversion, rendering them promising for biomedical applications.
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http://dx.doi.org/10.1039/c5nr01008j | DOI Listing |
Drug Deliv Transl Res
January 2025
Department of Pharmacology and Toxicology, Faculty of Pharmacy and Pharmaceutical Sciences Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran.
Agomelatine is an atypical antidepressant with a long half-life and the mechanism of action similar to melatonin. Agomelatine is a strong antioxidant and its anti-inflammatory effect has been reported in many studies. The current study aimed to evaluate the anti-inflammatory effect of agomelatine loaded in targeted nanoparticles (NPs) in an experimental colitis model induced by trinitrobenzene sulfonic acid (TNBS).
View Article and Find Full Text PDFJ Chromatogr A
January 2025
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK. Electronic address:
Research into nanoparticle interactions with biomolecules has become increasingly important in nanomedicine. While lipid nanoparticles (LNPs) are widely used as drug delivery systems, there remains a gap in understanding their fate in circulation, which is crucial for selecting appropriate lipids during formulation development. This study is the first to use Asymmetric Flow Field Flow Fractionation (AF4) to compare two types of LNPs: MC3-LNPs and SM-102-LNPs, and their interactions with a model protein, bovine serum albumin (BSA).
View Article and Find Full Text PDFExposure to ambient particulate matter (PM) with an aerodynamic diameter of <10 μm (PM) is a well-established health hazard. There is increasing evidence that geogenic (Earth-derived) particles can induce adverse biological effects upon inhalation, though there is high variability in particle bioreactivity that is associated with particle source and physicochemical properties. In this study, we investigated physicochemical properties and biological reactivity of volcanic ash from the April 2021 eruption of La Soufrière volcano, St.
View Article and Find Full Text PDFACS Nano
January 2025
Department of Geriatric Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 211166, P. R. China.
The protein corona effect refers to the phenomenon wherein nanomaterials in the bloodstream are coated by serum proteins, yet how protein coronated nanomaterials interact with blood vessels and its toxicity implications remain poorly understood. In this study, we investigated protein corona-related vessel toxicity by using an all-humanized assay integrating blood vessel organoids and patient-derived serum. Initially, we screened various nanomaterials to discern how parameters including size, morphology, hydrophobicity, surface charge, and chirality-dependent protein corona difference influence their uptake by vessel organoids.
View Article and Find Full Text PDFJ Liposome Res
November 2024
Department of Pharmaceutical Sciences, School of Health Sciences and Technology, UPES, Dehradun, India.
This work aimed to formulate surface-modified berberine hydrochloride (BER)-loaded liposomes containing nasal gel for bran targeting. The liposomes were prepared by ethanol-injection method and optimized following a 3 full-factorial design. Size, morphology, zeta potential, permeation, and release were estimated.
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