AI Article Synopsis
- Phytases break down phytic acid into lower forms of inositol phosphates, myo-inositol, and inorganic phosphate, which are vital for metabolism and signaling.
- These enzymes are crucial for enhancing phosphorus availability in animal feed, reducing pollution caused by animal waste.
- The Bacillus licheniformis-derived phytase (PhyL) exhibits unique properties that can enhance biotechnological applications, and its engineered version presents challenges and opportunities for improving functionality.
Article Abstract
Phytases catalyze the hydrolysis of phytic acid in a stepwise manner to lower inositol phosphates, myo-inositol (having important role in metabolism and signal transduction pathways), and inorganic phosphate. These enzymes have been widely used in animal feed in order to improve phosphorus nutrition and to decrease pollution in animal waste. Compared to previously described phytases, the phytase (PhyL) from Bacillus licheniformis ATCC 14580 has attractive biochemical properties which can increase the profitability of several biotechnological procedures (animal nutrition, humain health…etc). Due to its amino acid sequence with critical substitutions, the PhyL could be a model to enhance other phytases features, in terms of thermal stability and high activity. Otherwise, an engineered PhyL, with low pH optimum, will represent a challenge within the class of β- propeller phytases.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601277 | PMC |
| http://dx.doi.org/10.1080/21655979.2015.1048050 | DOI Listing |
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