AI Article Synopsis
- The study used a microfluidic device to investigate how hydraulic pressure affects H9c2 cardiomyoblast cells.
- A pressure of 170 mm Hg resulted in increased cell size and higher levels of atrial natriuretic peptide expression.
- The presence of a focal adhesion kinase inhibitor diminished the impact of hydraulic pressure, suggesting a new potential therapeutic approach for treating heart issues related to high blood pressure.
Article Abstract
We employed a microfluidic device to study the effects of hydraulic pressure on cardiomyoblast H9c2. The 170 mm Hg pressure increased the cellular area and the expression of atrial natriuretic peptide. With the same device, we demonstrated that the effects of hydraulic pressure on the cardiomyoblast could be reduced by the inhibitor of focal adhesion kinase. This mechanical-chemical antagonism could lead to a potential therapeutic strategy of hypertension-induced cardiac hypertrophy.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393411 | PMC |
| http://dx.doi.org/10.1063/1.4917080 | DOI Listing |
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