AI Article Synopsis
- The study examined the prevalence of osteoporosis in patients with systemic sclerosis (SSc) and evaluated bone tissue changes using High-Resolution peripheral Quantitative Computed Tomography (HR-pQCT).
- A total of 33 SSc patients were compared to 33 matched controls; results showed lower BMI, a higher osteoporosis prevalence, and decreased volumetric bone density (vBMD) in patients.
- Factors such as low lean body mass, older age, and the presence of specific antibodies were linked to lower bone mineral density (BMD) and alterations in bone microarchitecture.
Article Abstract
Purpose: Investigate the prevalence of osteoporosis in patients with systemic sclerosis (SSc) and describe alterations of bone tissue with High-Resolution peripheral Quantitative Computed Tomography (HR-pQCT).
Methods: Thirty-three patients and 33 controls matched on age, body mass index (BMI) and menopause were included. Bone mineral density (BMD) was measured at the lumbar spine (LS), femoral neck (FN) and total hip (TH) by dual energy X-ray absorptiometry. Volumetric BMD (vBMD) and bone microarchitecture were measured by HR-pQCT at tibia and radius.
Results: In patients, BMI was significantly lower, the prevalence of osteoporosis was significantly higher and HR-pQCT analysis showed a significant alteration of the trabecular compartment with a decrease in trabecular vBMD on both sites than in controls. In multivariate analysis, a low lean body mass, presence of anticentromere antibodies and older age were identified as independent factors for decreased BMD at LS (r²=0.43), FN (r²=0.61) and TH (r²=0.73). History or current digital ulcers were also identified as an independent factor for microarchitecture alteration.
Conclusions: In patients an increased prevalence of osteoporosis was found and HR-pQCT showed impaired trabecular bone compartment. Also, low lean body mass, high age, digital ulcers and ACAs were identified as independent risk factors for bone damage.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558121 | PMC |
| http://dx.doi.org/10.18632/oncotarget.3806 | DOI Listing |
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