Objective: The aim of the present study was to investigate the in vivo protective effects of hesperidin or diosmin or apigenin on damage induced by transient BCCAO and reperfusion.
Methods: Rat pial microcirculation was observed through a closed cranial window, using fluorescence microscopy. Pial arterioles were classified in five orders according to the Strahler's method.
Results: After 30 BCCAO and 60 minutes reperfusion, rats showed decreased arteriolar diameter, microvascular leakage, leukocyte adhesion, and reduction in capillary perfusion. Hesperidin and diosmin abolished the reduction in arteriolar diameter, while higher dose apigenin induced dilation by 21.7 ± 2.0% in order three arterioles RE. Nitric oxide synthase inhibition attenuated significantly hesperidin or diosmin or apigenin's effects on arteriolar diameter. Moreover, all these substances reduced microvascular leakage as well as leukocyte adhesion in dose-related manner, while capillary perfusion was protected. Furthermore, reduction in infarcted area and decrease in ROS production were observed.
Conclusions: Hesperidin, diosmin, and apigenin showed dose-related protective effects on hypoperfusion-reperfusion injury, causing nitric oxide release and attenuating tissue edema and leukocyte adhesion.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/micc.12207 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Hesperidin and Diosmin Increased Cytotoxic Activity Cisplatin on Hepatocellular Carcinoma and Protect Kidney Cells Senescence.
Asian Pac J Cancer Prev
December 2024
Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada (UGM), Sekip Utara, Yogyakarta 55281, Indonesia.
Objective: Cisplatin (Cisp) is a chemotherapy drug for treating liver cancer. Hesperidin (HSD), a flavanone, is known for its anticancer, and anti-inflammatory properties. Diosmin (DSM), a flavone glycoside, is known for its anti-oxidant effect.
View Article and Find Full Text PDF[Perception and knowledge of hemorrhoidal disease among healthcare professionals in Spain].
Semergen
December 2024
Centro de Salud Ponent, Andratx, Islas Baleares, España.
Introduction: Hemorrhoidal disease (HD) is a public health problem in our clinics and in the quality of life of patients, therefore it is necessary to analyze the actions in the management of HD by healthcare professionals in Spain.
Material And Methods: Observational, descriptive and cross-sectional study with data collection through a 28-question survey using a Google® form. 240 surveys were received.
Synergistic therapeutic approach for hemorrhoids: integrating mesenchymal stem cells with diosmin-hesperidin to target tissue edema and inflammation.
Arch Med Sci
October 2024
Doctoral program of Medical Sciences, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia.
Introduction: Mesenchymal stem cells (MSCs) have promising regenerative properties in tissue repair and anti-inflammatory responses. This study aimed to investigate the effects of MSCs and their combination with micronized purified flavonoid fraction (MPFF) in a croton oil-induced hemorrhoids model on tissue edema, inflammation, and underlying molecular mechanisms.
Material And Methods: MSCs were isolated and characterized for their adherence, differentiation capacity, and immunophenotyping.
Prescription versus over-the-counter venotonics: HPLC-DAD and static digestive model simulation comparison.
Int Angiol
October 2024
Transplantation Surgery Department, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Background: Venotonics are a class of therapeutically active molecules that have vaso-protective effects. They are used to alleviate venous diseases and disorders, particularly venous insufficiency. We compared the composition of prescription versus over-the-counter (OTC) venotonics using high-performance liquid chromatography with UV detection (HPLC-DAD) and simulating their digestion using a static digestive model.
View Article and Find Full Text PDFTailored biosynthesis of diosmin through reconstitution of the flavonoid pathway in .
Front Plant Sci
October 2024
Metabolic Engineering Division, National Institute of Agricultural Sciences, Rural Development Administration, Jeonju, Republic of Korea.
The flavonoid diosmin (diosmetin 7--rutinoside) is used as a therapeutic agent for disorders of the blood vessels such as hemorrhoids and varicose veins. Diosmin is commercially produced using semi-synthetic methods involving the oxidation of hesperidin, the most abundant flavonoid in citrus fruits. However, this method produces byproducts that are toxic to the environment, and new sustainable methods to produce diosmin are required.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!