Olfactory receptor genes cooperate with protocadherin genes in human extreme obesity.

Genes Nutr

Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420755PMChttp://dx.doi.org/10.1007/s12263-015-0465-3DOI Listing

Publication Analysis

Top Keywords

extreme obesity
16
olfactory receptor
8
receptor genes
8
predicted damaging
8
genes chromosome
8
obesity
6
genes
5
olfactory
4
genes cooperate
4
cooperate protocadherin
4

Similar Publications

Alström syndrome: the journey to diagnosis.

Orphanet J Rare Dis

January 2025

Department of Diabetes, Endocrinology and Metabolism, University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital, Birmingham, B15 2TH, UK.

Background: Alström syndrome (AS) is a recessively inherited genetic condition which is ultra-rare and extremely complex. Symptoms include retinal dystrophy, nystagmus, photophobia, hearing loss, obesity, insulin resistance, diabetes and cardiomyopathy. The condition is progressive, but it is important to note that not all the complications associated with AS occur in everyone affected.

View Article and Find Full Text PDF

Common salt (NaCl) causes developmental, behavioral, and physiological defects in .

Nutr Neurosci

January 2025

Neural Developmental Biology Lab, Department of Life Science, NIT Rourkela, Rourkela, Odisha, India.

Purpose: The incidence of obesity has surged to pandemic levels in recent decades. Approximately 1.89 million obesity are linked to excessive salt consumption.

View Article and Find Full Text PDF

[Indexing to Body Surface Area Diminishes GFR Estimation and Increases Chronic Kidney Disease Staging in Overweight and Obese Population].

Rev Med Chil

July 2024

Departamento de Nefrología, Escuela de Medicina, Facultad de Medicina, Universidad Católica de Chile, Santiago, Chile.

Unlabelled: Glomerular filtration rate estimates are usually indexed to a standard body surface area (BSA) of 1.73 m2. This allows comparing values of individuals of different sizes but has the potential of affecting individuals with extremes BSA.

View Article and Find Full Text PDF
Article Synopsis
  • Non-neoplastic hypercortisolaemia, or pseudo-Cushing's syndrome (PCS), can occur due to various health conditions like depression, obesity, and diabetes, linked to overactivity of the hypothalamic-pituitary-adrenal axis.
  • A 66-year-old woman exhibited symptoms such as weakness, weight loss, and poorly controlled hypertension, which led to the discovery of pheochromocytoma, a tumor that causes hormone overproduction, upon further testing.
  • After undergoing surgery to remove the tumor and receiving supportive treatment, her symptoms improved significantly, confirming the diagnosis of PCS rather than traditional Cushing's syndrome.
View Article and Find Full Text PDF
Article Synopsis
  • Obesity is a significant risk factor for venous thromboembolism (VTE) and poses unique challenges in anticoagulation management due to limited research on how extreme body weight affects medication outcomes.
  • This review focuses on patients with a body mass index (BMI) of 40 kg/m² or higher, analyzing various anticoagulants' dosages, efficacy, and safety for both prevention and treatment of VTE.
  • The study emphasizes the need for personalized treatment strategies and careful monitoring, especially for specific groups like cancer patients or those with kidney issues, given the insufficient evidence available for effective anticoagulant therapy in morbidly obese individuals.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!