AI Article Synopsis
- The study aimed to investigate and compare how mycophenolic acid (MPA) is processed in the bodies of lung transplant patients with cystic fibrosis (CF) versus those without it (NCF) after taking the drug mycophenolate mofetil (MMF).
- Researchers conducted three pharmacokinetic (PK) visits over time, using nonlinear mixed effects modeling to understand how different factors influence MPA metabolism and clearance.
- Results showed that CF patients absorb MPA more slowly and have higher clearance rates and distribution volumes than NCF patients, indicating the need for careful monitoring of MPA levels in CF patients to optimize treatment.
Article Abstract
Purpose: The objective of this work was to characterize and compare the population pharmacokinetics (PK) mycophenolic acid (MPA) in adult lung transplant recipients with cystic fibrosis (CF) and without the disease (NCF) following repeated oral administration of the prodrug mycophenolate mofetil (MMF) as an immunosuppressant.
Methods: Three separate 12-h PK visits were conducted for lung transplant patients with or without CF following repeated MPA treatment with at least a 2-week break between the visits. A population PK model was developed using nonlinear mixed effects modeling (NONMEM), and the contribution of physiological and pathological factors and time dependence of apparent oral clearance (CL/F) were assessed.
Results: For both CF and NCF patients, MPA serum concentration-time profiles were best described by a two-compartment PK model with first-order absorption. CF patients had a slower absorption rate (Ka), and elevated CL/F and volume of distribution (Vd/F) compared with NCF patients. There is a significant contribution of body weight and CF disease to MPA CL/F, and both were included in the final model as covariates.
Conclusions: The population PK model developed from our study successfully characterizes the absorption, distribution, and elimination of MPA in lung transplant recipients with or without CF disease. The decrease of MPA absorption and increase of both oral clearance (CL/F) and volume of distribution (V2/F and V3/F) in the CF patients would suggest the importance of MPA therapeutic monitoring for this group.
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| http://dx.doi.org/10.1007/s00228-015-1854-7 | DOI Listing |
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