Reduced activity of the growth-regulating TOR complex 1 induces transcription of many genes. In this issue of Developmental Cell, Tiebe et al. (2015) identify a transcriptional regulator complex repressed by TORC1 and responsible for a vast majority of the observed transcriptional changes in Drosophila.
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Department of Public Health, Graduate School of Public Health, Seoul National University, Seoul, South Korea.
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Department of Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.
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According to World Health Organization (WHO) data, 16% of people are affected by infertility across the globe. One underlying factor is the age-related decline of ovarian reserve (DOR), which can lead to a higher chance of infertility and has no widely accepted treatment currently. Specific supplements and moderate exercise have been shown to improve fertility; however, there is no consensus to date on the type of exercise providing the best results.
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