AI Article Synopsis
- Heart development involves myocyte specification, differentiation, and cardiac morphogenesis, regulated by core cardiac transcription factors.
- Histone methylation is an important epigenetic mechanism that influences gene transcription and works alongside cardiac transcription factors and histone lysine modifiers during heart development.
- Mutations or abnormal expression of histone modifiers can lead to serious consequences, including embryonic death or congenital heart diseases, and affect how adult hearts handle stress.
Article Abstract
Heart development comprises myocyte specification, differentiation and cardiac morphogenesis. These processes are regulated by a group of core cardiac transcription factors in a coordinated temporal and spatial manner. Histone methylation is an emerging epigenetic mechanism for regulating gene transcription. Interplay among cardiac transcription factors and histone lysine modifiers plays important role in heart development. Aberrant expression and mutation of the histone lysine modifiers during development and in adult life can cause either embryonic lethality or congenital heart diseases, and influences the response of adult hearts to pathological stresses. In this review, we describe current body of literature on the role of several common histone methylations and their modifying enzymes in heart development, congenital and adult heart diseases.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451103 | PMC |
| http://dx.doi.org/10.2217/epi.14.60 | DOI Listing |
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