Immunosuppressive pathways active within the tumor microenvironment must be targeted in combination to sufficiently bolster antitumor immune defenses. Inhibition of A adenosine receptor signaling in combination with immune checkpoint blockade enhances CD8 T and NK cell anti-metastatic activity. This results in reduced metastatic burden and improved survival in pre-clinical models.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292728 | PMC |
| http://dx.doi.org/10.4161/21624011.2014.958952 | DOI Listing |
Publication Analysis
Top Keywords
adenosine receptor
8
co-blockade immune
4
immune checkpoints
4
checkpoints adenosine
4
receptor suppresses
4
suppresses metastasis
4
metastasis immunosuppressive
4
immunosuppressive pathways
4
pathways active
4
active tumor
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!