The goal of this review is to summarize current evidence for sex differences in the response to cannabinoid compounds, focusing mainly on a specific age of exposure, i.e., adolescence. Preclinical as well as clinical studies are examined. Among the different possible underlying mechanisms, the consistent dimorphism in the endocannabinoid system and delta9-tetrahydrocannabinol metabolism may play a part. All the collected data point to the need of including females in basic research as well as of analyzing results for sex differences in epidemiological studies.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403248 | PMC |
| http://dx.doi.org/10.3389/fpsyt.2015.00056 | DOI Listing |
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