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Atypical teratoid rhabdoid tumor: long-term survival after chemoradiotherapy. | LitMetric

Atypical teratoid rhabdoid tumor: long-term survival after chemoradiotherapy.

Childs Nerv Syst

Department of Radiation Oncology, University of Nebraska Medical Center, 987521 Nebraska Medical Center, Omaha, NE, USA,

Published: August 2015

AI Article Synopsis

Article Abstract

Purpose: Atypical teratoid rhabdoid tumors (ATRTs) arise from the central nervous system largely in the pediatric population. They portend a very poor prognosis with few long-term survivors. We describe a series of five cases at our institution.

Methods: We conducted a retrospective chart review and clinical follow-up.

Results: Three patients underwent chemoradiation after surgical resection; the two patients whose caretakers declined this therapy passed away soon after diagnosis. Chemoradiation included intravenous and intrathecal chemotherapy as well as intensity-modulated radiotherapy after resection. Of the patients receiving chemoradiation, two patients had infratentorial tumors, two had gross residual tumor after resection, and two were under the age of 3 years. The three patients receiving trimodality therapy remain clinically and symptomatically disease-free with follow-up times of 44, 46, and 55 months. Two of the patients have mild neuropsychiatric sequelae after therapy.

Conclusions: Long-term, high-volume trials of ATRT are currently not published. We offer experience in successful long-term survival of this tumor treated with chemoradiotherapy.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00381-015-2723-5DOI Listing

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