AI Article Synopsis
- This study investigates the heritability of infant attachment disorganization and security, which has not been extensively researched despite environmental influences being well-studied.
- It utilizes a large sample of 657 ethnically homogenous 14-month-old children to conduct a Genome-Wide Association Study (GWAS) to identify specific genetic markers (SNPs) linked to these attachment styles.
- Findings reveal new genes and pathways related to attachment disorganization, but only one novel gene associated with attachment security, indicating the need for further research to confirm these results.
Article Abstract
Although the environmental influences on infant attachment disorganization and security are well-studied, little is known about their heritability. Candidate gene studies have shown small, often non-replicable effects. In this study, we gathered the largest sample (N = 657) of ethnically homogenous, 14-month-old children with both observed attachment and genome-wide data. First, we used a Genome-Wide Association Study (GWAS) approach to identify single nucleotide polymorphisms (SNPs) associated with attachment disorganization and security. Second, we annotated them into genes (Versatile Gene-based Association Study) and functional pathways. Our analyses provide evidence of novel genes (HDAC1, ZNF675, BSCD1) and pathways (synaptic transmission, cation transport) associated with attachment disorganization. Similar analyses identified a novel gene (BECN1) but no distinct pathways associated with attachment security. The results of this first extensive, exploratory study on the molecular-genetic basis of infant attachment await replication in large, independent samples.
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| http://dx.doi.org/10.1080/14616734.2015.1037316 | DOI Listing |
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