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A high-contrast NIR excitation probe for monitoring Cu in the endoplasmic reticulum for synergistic cuproptosis and ferroptosis anticancer therapy.
Nanoscale
January 2025
School of Chemistry and Chemical Engineering, Center of Free Electron Laser & High Magnetic Field, Key Laboratory of Structure and Functional Regulation of Hybrid Materials Ministry of Education, Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, and Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials of Anhui Province, Anhui University, P.R. China.
Currently, the study of cuproptosis focuses on the Cu-induced morphology changes in mitochondria (Mito), and the observation of the effect of endoplasmic reticulum (ER)-related Cu content on cuproptosis is relatively lacking. Herein, we have developed a hydroxyflavone (HF)-based NIR excited two-photon fluorescent probe, BHCO, that exhibits specific recognition of Cu with high resolution. BHCO-Cu (Cu2BC) can lead to DLAT protein aggregation, triggering cuproptosis.
View Article and Find Full Text PDFNear-Infrared Two-Photon J-Aggregation-Induced Organic Fluorescent Dots with Large Stokes-Shift for Ratiometric Imaging of Hypochlorous Acid in Living Cells and Brains of AD Mice.
Adv Healthc Mater
November 2024
Anhui Provincial Key Laboratory of Biomedical Materials and Chemical Measurement, Laboratory of Functionalized Molecular Solids, Ministry of Education, College of Chemistry and Materials Science, Anhui Normal University, Wuhu, 241002, China.
Alzheimer's disease (AD) is characterized by multiple toxicity from various biomarkers, and it is very important to monitor the fluctuation of biomarker level in brain tissues to track its early onset, illness progression, and therapeutic effect. Hypochlorous acid (HOCl) is confirmed to be a reliable biomarker to extend the scope of diagnosis. However, the practical applications of the developed conjugated small molecule fluorescent probes for detecting HOCl are often restricted to a large extent by their low solubility, aggregation-caused quenching (ACQ), unsatisfactory fluorescence brightness, small Strokes-shift, and lack of self-correcting ratiometric emitters.
View Article and Find Full Text PDFDevelopment of a small molecule-based two-photon photosensitizer for targeting cancer cells.
J Mater Chem B
December 2024
Department of Energy Systems Research and Department of Chemistry, Ajou University, Suwon 16499, Korea.
Article Synopsis
- Researchers developed BSe-B, a new photosensitizer for two-photon photodynamic therapy (TP-PDT) that targets cancer cells while sparing normal cells.
- BSe-B combines a selenium-based dye with a biotin ligand for cancer selectivity, showcasing low toxicity and effective generation of reactive oxygen species.
- The study's findings confirm BSe-B's potential for precise cancer treatment and imaging, making it a valuable tool for both diagnosis and therapy in cancer care.
Diradicaloid-Loaded Polypeptide Nanoparticles for Two-Photon NIR Phototheranostics.
ACS Appl Mater Interfaces
November 2024
Department of Hepatobiliary Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Jinzai Road 96, 230026 Hefei, Anhui, P. R. China.
Article Synopsis
- - Stable organic radicals are being explored for their potential as high-fluorescence dyes, specifically looking at transitions from the ground state to an excited state.
- - A new compound called TFC-I was synthesized, achieving nearly 100% photoluminescence quantum yield (PLQY) and was incorporated into nanoparticles, creating P-TI, which showed strong features like high photostability and efficient ROS generation.
- - P-TI proved effective for targeted photodynamic therapy, deep tissue imaging, and demonstrated good safety in tests, highlighting the benefits of using organic radicals in medical applications.
Imaging α-synuclein pathologies in animal models and patients with Parkinson's and related diseases.
Neuron
August 2024
Advanced Neuroimaging Center, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan; Department of Neuroetiology and Diagnostic Science, Osaka Metropolitan University Graduate School of Medicine, Osaka 545-8585, Japan.
Article Synopsis
- A new small-molecule ligand called C05-05 has been developed to visualize α-synuclein deposits in the brains of living subjects, which is important for understanding Parkinson's disease (PD) and dementia with Lewy bodies (DLB).
- In studies involving mouse and marmoset models, C05-05 enabled detection of dynamic changes in α-synuclein fibril formation and structural disruptions within neural pathways.
- PET imaging revealed that C05-05 signals were significantly stronger in the midbrains of PD and DLB patients compared to healthy individuals, suggesting its potential for diagnostic and therapeutic advancements in these conditions.
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