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Platelets as crucial players in the dynamic interplay of inflammation, immunity, and cancer: unveiling new strategies for cancer prevention.
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Systems Pharmacology and Translational Therapeutics Laboratory, The Center for Advanced Studies and Technology (CAST), "G. d'Annunzio" University, Chieti, Italy.
Inflammation plays a critical role in the pathogenesis of various diseases by promoting the acquisition of new functional traits by different cell types. Shared risk factors between cardiovascular disease and cancer, including smoking, obesity, diabetes, high-fat diet, low physical activity, and alcohol consumption, contribute to inflammation linked to platelet activation. Platelets contribute to an inflammatory state by activating various normal cells, such as fibroblasts, immune cells, and vascular cells.
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Mol Ther Methods Clin Dev
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Research Institute, Children's Hospital of Orange County, Orange, CA, USA.
Mucopolysaccharidosis type I (MPS I) is a metabolic disorder characterized by a deficiency in α-l-iduronidase (IDUA), leading to impaired glycosaminoglycan degradation. Current approved treatments seek to restore IDUA levels via enzyme replacement therapy (ERT) and/or hematopoietic stem cell transplantation (HSCT). The effectiveness of these treatment strategies in preventing neurodegeneration is limited due to the inability of ERT to penetrate the blood-brain barrier (BBB) and HSCT's limited CNS reconstitution of IDUA levels.
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BMC Public Health
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School of Public Health, Heinz Mehlhorn Academician Workstation, Hainan Medical University, Haikou, 571199, Hainan, People's Republic of China.
Background: Hainan is a tropical island in China with a large migratory population. Study have reported that the blood pressure of Hainan elderly hypertensive migratory population decreased significantly, which may be related to the improvement of environment and quality of life (QoL). Understanding the changes of QoL of these people before and after coming to Hainan and its influencing factors can provide a basis for the prevention and control of hypertension.
View Article and Find Full Text PDFDetails on the transport of European eel larvae through the Strait of Gibraltar into the Mediterranean Sea.
Sci Rep
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Thünen Institute of Fisheries Ecology, Federal Research Institute for Rural Areas, Forestry and Fisheries, 27572, Bremerhaven, Germany.
Numbers of European glass eels (Anguilla anguilla) monitored along the Atlantic and Mediterranean coasts of Europe currently serve as the main stock indicator in assessment of this critically endangered species. Spawning, however, takes place exclusively in the Sargasso Sea, several thousand kilometers away. The beginning of its complex lifecycle is characterized by a distant and lengthy larval drift, before the young-of-the-year reach the monitoring stations at the European coasts.
View Article and Find Full Text PDFIdentity, language and communication concerns of subcultures: The case of Antalya Cretans.
PLoS One
January 2025
Faculty of Education, Akdeniz University, Antalya, Turkey.
In today's world, there is almost no homogeneous culture without interaction, and multiculturalism has become the most important phenomenon for all societies. Therefore, this cultural diversity, consisting of differences in culture, language, identity, religion, etc. has also brought along many problems.
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