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The prevalence of non-sentinel lymph node metastasis among breast cancer patients with sentinel lymph node involvement and its impact on clinical decision-making: a single-centred retrospective study.
Oncol Rev
October 2024
Department of Radiation Oncology, Affiliated Rehabilitation Hospital of Nanchang University, Nanchang, Jiangxi, China.
Article Synopsis
- Sentinel lymph node biopsy (SLNB) is standard for early breast cancer patients, revealing significant non-sentinel lymph node (non-SLN) metastasis rates, impacting treatment choices.
- A study of 892 female patients showed that 56.5% with positive sentinel lymph nodes had non-SLN metastasis, with rates increasing alongside the number of positive SLNs.
- Findings indicated that non-SLN metastasis is linked to various factors like tumor size and grade, suggesting that precise staging can guide more effective treatment strategies for breast cancer patients.
Incidental dose distribution to contralateral internal mammary nodes in breast cancer patients undergoing adjuvant radiotherapy.
Clin Transl Radiat Oncol
September 2024
Department of Radiation Oncology, TUM School of Medicine and Health, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Article Synopsis
- The study investigates the lymphatic drainage to contralateral internal mammary nodes (cIMN) in breast cancer patients and highlights its neglect in current adjuvant radiotherapy practices.* -
- It analyzes the incidental radiation dose to cIMN in 120 advanced treatment plans, noting that higher doses are observed when including internal mammary node irradiation (IMNI) and during free breathing compared to deep inspiration breath hold (DIBH).* -
- The findings indicate that cIMN receives low radiation doses in existing randomized trials and treatment methods, prompting the need for further research on the effects of targeting cIMN in high-risk breast cancer patients.*
Clinical Experience of Axillary Radiotherapy for Node-positive Breast Cancer.
Clin Oncol (R Coll Radiol)
February 2024
Beatson West of Scotland Cancer Centre, Gartnavel Hospital, NHS Greater Glasgow & Clyde, Glasgow, UK.
Aims: Patients with breast cancer who have positive lymph nodes are currently recommended axillary node clearance (ANC) or regional nodal irradiation (RNI). ANC is associated with complications such as lymphoedema, brachial plexopathy and shoulder stiffness. The AMAROS Group showed RNI to be non-inferior to ANC with regards to survival and recurrence, and with a better quality of life.
View Article and Find Full Text PDFNomogram based on multiparametric analysis of early-stage breast cancer: Prediction of high burden metastatic axillary lymph nodes.
Thorac Cancer
December 2023
The Third Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
Background: The Z0011 and AMAROS trials found that axillary lymph node dissection (ALND) was no longer mandatory for early-stage breast cancer patients who had one or two metastatic axillary lymph nodes (mALNs). The aim of our study was to establish a nomogram which could be used to quantitatively predict the individual likelihood of high burden mALN (≥3 mALN).
Methods: We retrospectively analyzed 564 women with early breast cancer who had all undergone both ultrasound (US) and magnetic resonance imaging (MRI) to examine axillary lymph nodes before radical surgery.
Reconsidering the Role of Frozen Section in Sentinel Lymph Node Biopsy for Mastectomy Patients.
J Surg Res
January 2024
Department of Surgery, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. Electronic address:
Introduction: Axillary lymph node dissection was recommended for mastectomy patients with more than two nodal metastases from sentinel lymph node biopsy. Conventionally, intraoperative frozen section was sent routinely to reduce the need for second-stage axillary lymph node dissection; however, recent global trend has seen decreasing usage of the intraoperative analyses. This pilot study conducted in Thailand aimed to evaluate the role of intraoperative frozen section of sentinel lymph node biopsy in early-stage breast cancer patients who underwent mastectomy.
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