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Lactams Exhibit Potent Antifungal Activity Against Monospecies and Multispecies Interkingdom Biofilms on a Novel Hydrogel Skin Model.
APMIS
January 2025
Oral Sciences Research Group, Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, Glasgow, UK.
Infections of intact and damaged skin barriers and keratin are frequently associated with complex biofilm communities containing bacteria and fungi, yet there are limited options for successful management. This study intended to focus on the utility of some novel proprietary lactam molecules, quorum sensing (QS)-derived halogenated furanones, which act to block the QS pathway, against key fungal pathogens of the skin (Candida albicans, Malassezia furfur and Microsporum gypseum). Moreover, we aimed to assess how these actives performed against complex interkingdom biofilms in a clinically relevant model.
View Article and Find Full Text PDFAI-Based Analysis of Ziehl-Neelsen-Stained Sputum Smears for as a Screening Method for Active Tuberculosis.
Life (Basel)
November 2024
Department of Pathology, Colentina University Hospital, 21 Stefan Cel Mare Str., Sector 2, 020125 Bucharest, Romania.
Tuberculosis is the primary cause of death due to infection in the world. Identification of in sputum is a diagnostic test, which can be used in screening programs-especially in countries with a high incidence of tuberculosis-to identify and treat those persons with the highest risk of disseminating the infection. We previously developed an algorithm which is able to automatically detect mycobacteria on tissue; in particular, our algorithm identified acid-fast bacilli on tissue with 100% specificity, 95.
View Article and Find Full Text PDFIsolation and Whole-Cell Patch-Clamp Recording of Hippocampal Microglia from Adult Mice.
J Vis Exp
September 2024
School of Life Sciences, Guangzhou University;
Article Synopsis
- * The traditional method for studying microglial activity involves using cells from fetal or newborn mice, making it challenging to study adult microglia.
- * This study presents a new protocol for isolating adult mouse hippocampal microglia and performing whole-cell patch-clamp recordings, confirming successful isolation through specific antibody staining.
Dual PD-L1/SOX10 Immunohistochemistry Combined With Digital Imaging Enhances Stratification Accuracy of Patients With Metastatic Melanoma.
Am J Surg Pathol
October 2024
Department of Pathology.
Article Synopsis
- Immune checkpoint inhibitors have shown to improve survival in advanced melanoma, but the role of PD-L1 expression as a predictor of patient response is still uncertain.
- A study involving 36 biopsies of untreated metastatic melanoma patients found significant discrepancies in PD-L1 expression categorization when re-evaluated using a dual staining technique with SOX10, revealing that many cases were downgraded in their PD-L1 scores.
- This dual immunohistochemistry approach may enhance the accuracy of PD-L1 assessment, helping to make better clinical decisions about whether to use single or combination immunotherapy, ultimately affecting patient outcomes and quality of life.
Establishment of a rapid, cost-effective, and accurate method for assessing insect sperm viability.
J Insect Physiol
October 2024
Department of Biology, Faculty of Science and Engineering, Konan University, 8-9-1 Okamoto, Higashinada-ku, Kobe 658-8501, Japan; Institute for Integrative Neurobiology, Konan University, 8-9-1 Okamoto, Higashinada-ku, Kobe 658-8501, Japan; Suntory Rising Stars Encouragement Program in Life Sciences (SunRiSE), Japan. Electronic address:
High-quality sperm cells are crucial to reproductive success for both males and post-mating females in animals. Sperm viability, defined as the proportion of viable sperm cells, is used as a sperm quality index and this method has provided new insights into research on reproductive strategies. Sperm viability has been assessed by fluorescent staining of sperm cells.
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