Background: The alignment of the knee in the transverse plane is important to the biomechanical functions of the lower limb, and is also associated with the outcomes of the total knee arthroplasty. This study aimed to evaluate the dynamic tibiofemoral alignment in the transverse plane during a weight-bearing activity.
Methods: Knee kinematics of weight-bearing flexion from 0° to 120° was obtained in 16 healthy subjects utilizing biplanar radiography and 3D-2D registration techniques. The anteroposterior axes of the femur at multiple flexion angles in the range of knee motion were used to calculate the anteroposterior axis of motion using the least square method. The latter was compared to six surface-derived anatomical axes in the proximal tibia which were most commonly reported in the literature. The relationship between the anteroposterior axis of motion and the tibial tubercle was also quantified.
Findings: The anteroposterior axis of motion did not coincide with any of the six anatomical axes tested. Their orientations varied from 10.3° of external rotation to 9.9° of internal rotation in relation to the former. The anteroposterior axis of motion tended to intersect the tibial tubercle between the medial border and the medial 1/3 point.
Interpretation: Instead of any of the tested anatomical axes, the transverse knee alignment during functional movements is associated with the medial 1/3 portion of the tibial tubercle. This region may be helpful for the rotational alignment of the tibial components in total knee arthroplasty.
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http://dx.doi.org/10.1016/j.clinbiomech.2015.04.003 | DOI Listing |
J Bone Joint Surg Am
February 2025
Department of Orthopaedic Surgery and Traumatology, Hospital and University of Fribourg, Fribourg, Switzerland.
Background: The medial patellofemoral ligament (MPFL) serves as the primary stabilizer of the patellofemoral joint, and surgical reconstruction aims to replicate its biomechanical properties. However, misplacement of the femoral tunnel remains a major problem that leads to revision after surgery for patellar instability. The C-arm technique for identifying the femoral origin of the MPFL (fMPFL) during surgery may not account for individual variability.
View Article and Find Full Text PDFFoot Ankle Surg
February 2025
University of Basel, Basel, Switzerland; Orthopedic Surgery & Traumatology, Mein Fusszentrum AG, Basel, Switzerland. Electronic address:
Background: Lower limb alignment on plain radiographs is commonly examined in orthopedics. Measurement of the medial distal tibial angle (MDTA) requires determining the tibial axis. Traditionally, in orthopedic practice, anatomical or surgical axes have been used.
View Article and Find Full Text PDFJ Orthop Surg Res
February 2025
Department of Orthopaedic Surgery, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
Objective: The purpose of this study was to investigate the distribution of the change of leg length (LL) after closed wedge high tibial osteotomy (CWHTO) and to identify the factors associated with the magnitude of postoperative change of LL.
Methods: A total of 70 consecutive knees of 58 patients with knee osteoarthritis who underwent CWHTO were retrospectively investigated. LL, hip-knee-ankle angle (HKAA), mechanical axis deviation (MAD), joint line convergence angle (JLCA), mechanical medial proximal tibial angle (mMPTA), and mechanical lateral distal femoral angle (mLDFA) were measured using the anteroposterior whole leg radiograph, and posterior tibial slope (PTS) and flexion contracture (FC) were measured using the lateral knee radiograph.
J Cell Biol
April 2025
Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
The process of folding the flat neuroectoderm into an elongated neural tube depends on tissue fluidity, a property that allows epithelial deformation while preserving tissue integrity. Neural tube folding also requires the planar cell polarity (PCP) pathway. Here, we report that Prickle2 (Pk2), a core PCP component, increases tissue fluidity by promoting the remodeling of apical junctions (AJs) in Xenopus embryos.
View Article and Find Full Text PDFCommun Med (Lond)
February 2025
Department of Bioengineering, Stanford University, Stanford, CA, USA.
Introduction: Current mitral annuloplasty rings fail to restrict the anteroposterior distance while allowing dynamic mitral annular changes. We designed and manufactured a mitral annuloplasty ring that demonstrated axis-specific, selective flexibility to meet this clinical need. The objectives were to evaluate ex vivo biomechanics of this ring and to validate the annular dynamics and safety after ring implantation in vivo.
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